The cytopathic effect of hiv is associated with apoptosis

Laurent-Crawford, Anne G.; Krust, Bernard; Muller, Sylviane; Rivière, Yves; Rey-Cuillé, Marie-Anne; Béchet, Jean-Marie; Montagnier, Luc; Hovanessian, Ara G.

doi:10.1016/0042-6822(91)90554-o

Cited by 340 publications

(143 citation statements)

References 44 publications

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“…Recently, several reports suggested that apoptosis contributes to the loss of lymphocytes in FIV and HIV infections [12,17,22,26,[28][29][30]40]. However, apoptotic cells could not be confirmed in the lymph nodes examined in this study.…”

Section: Discussioncontrasting

confidence: 83%

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

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ABSTRACT. Alterations of T-cell subsets in the lymph nodes from FIV-infected cats in various clinical disease stages were examined histologically. In the early stage of infection (AP stage), follicular hyperplasia accompanied by expansion of the paracortical area was observed. Follicular involution and depletion with reduced paracortical area was observed in the ARC and AIDS stage nodes. The maximum section area of the entire popliteal lymph node was expanded significantly in the AP nodes. The paracortical area expanded in the AP nodes and decreased in the ARC and AIDS stage nodes. The cell density in the paracortical area in the AP nodes did not show a significant increase, while there was a significant reduction in the ARC and AIDS stage nodes. The lymph node CD4/CD8 ratio in the AP and ARC stages significantly decreased as compared with that of uninfected control cats, but conversion of the ratio was not seen. The estimated total numbers of CD4 + and CD8 + cells in the maximum section were increased in the AP stage but significantly decreased in the ARC and AIDS stages. Our study indicated that the lymphocyte depletion in the terminal ARC and AIDS stages of FIV infection was associated with both CD4 + cells and CD8 + cells. Findings obtained in this study might provide useful information for studying the pathophysiology of FIV infection. -KEY WORDS: CD4, CD8, feline immunodeficiency virus, lymph node.

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Section: Discussioncontrasting

confidence: 83%

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

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“…31 Parallel studies showed that a marked fraction of both infected and uninfected T cells from HIV-positive individuals die by apoptosis ex vivo, either spontaneouly following a short-term incubation, or after TCR-triggering, [3][4][5][6][7] as do HIV-infected T cells in vitro. [32][33][34] The mechanisms that are involved in HIV-associated apoptosis of lymphocyte include: direct killing of infected target cells following virus-gene expression and cytopathicity, death of bystander cells by proapoptotic viral proteins released by infected cells, killing of HIV-specific effectors following their recruitment to infected lymphoid tissues, and altered expression of cellular apoptosis regulatory molecules on lymphocytes and antigen-presenting cells (APCs) as a consequence of HIV-mediated immune activation. 35 …”

Section: How Hiv Exploits the Apoptotic Machinerymentioning

confidence: 99%

To kill or be killed: how HIV exhausts the immune system

Gougeon

2005

Cell Death Differ

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“…Apoptosis is thought to play a key role in embryogenesis (Pierce et al, 1989), carcinogenesis (Vaux et al, 1988), and the killing of virally infected cells (Laurent-Crawford et al, 1991). Although apoptosis is initiated by many physiological and pathological stimuli, all apoptotic cells undergo a similar sequence of morphological and biochemical events (Martin et al, 1994), which include condensation of the chromatin in the nucleus; fragmentation of DNA into fragments with lengths that are multiples of approximately 180 bp, as a result of speci®c cleavage between nucleosomes by an endogenous endonuclease; and a relatively high degree of preservation of the plasma membrane and cytoplasmic organelles.…”

Section: Introductionmentioning

confidence: 99%

Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells

et al. 1999

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Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various lines of human tumor cells, such as leukemia HL60 and U937 cells, by altering the expression of apoptosis-related genes, for example, bcl-2 and c-myc. In this study, we characterized a gene that is involved in bufalin-induced apoptosis by the di erential display (DD) technique. The partial nucleotide sequence of one of the di erentially expressed clones obtained after treatment with bufalin was identical to that of the human gene for Tiam1. When U937 cells were treated with 10 77 M bufalin, expression of both Tiam1 mRNA and the protein was induced 1 h after the start of the treatment. The increase of Tiam1 mRNA was transient but the level of Tiam1 protein continued to increase at least for 6 h. In addition, the activities of Rac1 and p21-activated kinase (PAK) were also stimulated by bufalin treatment. To evaluate the role of Tiam1 in the apoptotic process, we examined the e ects of the expression of sense and antisense RNA for Tiam1 in U937 cells. Apoptosis was strongly induced by bufalin in cells that expressed sense RNA for Tiam1 as compared to apoptosis in control cells treated with bufalin only. Cells expressing antisense RNA for Tiam1 were signi®cantly more resistant than the control bufalin-treated cells to induction of DNA fragmentation in response to bufalin. Moreover, sense transformants had elevated activities of PAK and c-Jun NH 2 -terminal kinase (JNK). These results suggest that Tiam1 might play a critical role in bufalin-induced apoptosis through the activation of Rac1, PAK, and JNK pathway.

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The cytopathic effect of hiv is associated with apoptosis

Cited by 340 publications

References 44 publications

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

To kill or be killed: how HIV exhausts the immune system

Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells

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