The Cytology of a Thyroid Granular Cell Tumor

Su, Chang; Wei, Chang‐Kuo; Tseng, Chih-En

doi:10.1007/s12022-009-9071-5

Cited by 13 publications

(17 citation statements)

References 8 publications

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“…GCTs are thought to arise from peripheral nerve sheath cells, but are associated with both neural and histiocytic differentiation. The cytological features previously reported are similar to our thyroid GCT findings: large cells with abundant granular cytoplasm with indistinct borders and fairly uniform, generally spherical small nuclei with inconspicuous nucleoli, and a background of naked nuclei with granular debris 3,4 …”

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confidence: 88%

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Fine needle aspiration cytology of a granular cell tumour arising in the thyroid gland

et al. 2011

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supporting

confidence: 88%

“…To our knowledge, eight primary GCTs of the thyroid gland have been previously reported; only two of the reports described cytological findings obtained by fine needle aspiration (FNA). 3,4 We describe a case of thyroid GCT together with its radiological [computed tomography (CT) and sonography] and cytopathological characteristics.…”

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confidence: 99%

Fine needle aspiration cytology of a granular cell tumour arising in the thyroid gland

et al. 2011

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“…However, classic black thyroid findings include blue-gray cytoplasm with dark-brown granules and colloid can often be seen in the background. [12] Finally, because of the increased surveillance of thyroid nodules, a histiocytic reaction to a previous FNA should be considered. Histiocytes with foamy granular cytoplasm may mimic the cells of GCT, however the nuclei tend to be reniform as opposed to round and oval and the cytoplasm more foamy than granular.…”

Section: Discussionmentioning

confidence: 99%

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

2014

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Background:Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of neural origin. The cytomorphological features range from highly cellular to scanty cellular smears with dispersed polygonal tumor cells. The cells have abundant eosinophilic granular cytoplasm, eccentric round to oval vesicular nuclei with small inconspicuous nucleoli. The fragility of the cells can result in many stripped nuclei in a granular background. The differential diagnosis occasionally can range from a benign or reactive process to features that are suspicious for malignancy. Some of the concerning cytologic features include necrosis, mitoses and nuclear pleomorphism.Methods:We identified 6 cases of suspected GCT on cytology within the last 10 years and compared them to their final histologic diagnoses.Results:Four had histologic correlation of GCT including one case that was suspicious for GCT on cytology and called atypical with features concerning for a malignant neoplasm. Of the other two cases where GCT was suspected, one showed breast tissue with fibrocystic changes, and the other was a Hurthle cell adenoma of the thyroid.Conclusions:These results imply that FNA has utility in the diagnosis of GCT, and should be included in the differential diagnoses when cells with abundant granular cytoplasm are seen on cytology. Careful attention to cytologic atypia, signs of reactive changes, use of immunohistochemistry, and clinical correlation are helpful in arriving at a definite diagnosis on FNA cytology.

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“…GCTs of the thyroid gland are rare with only six previously reported cases in the English language literature [6][7][8][9][10][11]. Furthermore, Park et al [12] reported a case of multiple granular cell lesions in a 29-week-old male foetus involving sites such as the kidneys, gingivae and testes, as well as the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumour of the Thyroid Gland: A Case Report and Review of the Literature

2011

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Granular cell tumours of the thyroid gland are rare, with only six previously reported cases in the English literature. Current histological, immunohistochemical and electron microscopic evidence favours a neural/Schwannian relationship. A case of a granular cell tumour of the thyroid gland in a healthy 36-year-old woman is described. The tumour was found incidentally following a right thyroid lobectomy for symptoms from an asymmetric multinodular goitre. Macroscopically, the lesion resembled a papillary microcarcinoma. Microscopically, the tumour was composed of nests of epithelioid cells with abundant granular, eosinophilic cytoplasm. The nests were divided by fibrous septa and peripherally interdigitated with surrounding thyroid follicles. Immunohistochemistry helped to distinguish the lesion from other neoplasms such as Hurthle cell tumour, medullary carcinoma or metastasis, and also from a histiocytic reaction to previous fine needle aspiration. On the basis of this diagnosis, no further intervention was required, and the patient was discharged following post-operative review.

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The Cytology of a Thyroid Granular Cell Tumor

Cited by 13 publications

References 8 publications

Fine needle aspiration cytology of a granular cell tumour arising in the thyroid gland

Fine needle aspiration cytology of a granular cell tumour arising in the thyroid gland

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

Granular Cell Tumour of the Thyroid Gland: A Case Report and Review of the Literature

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