The cytokine-serum amyloid A-chemokine network

Buck, Mieke De; Gouwy, Mieke; Wang, Ji Ming; Snick, Jacques Van; Struyf, Sofie; Damme, Jozef Van

doi:10.1016/j.cytogfr.2015.12.010

Cited by 110 publications

(115 citation statements)

References 140 publications

(306 reference statements)

Supporting

Mentioning

110

Contrasting

Order By: Relevance

“…SAA exhibits significant immunological activity being chemotactic for neutrophils and mast cells, and takes part to the so called cytokine-serum amyloid A-chemokine network (De Buck et al, 2016). In humans, SAA can act as pathogenic pattern recognition protein by opsonizing Gramnegative bacteria, increasing meanwhile macrophages and neutrophil phagocytosis (Shah et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Widespread extrahepatic expression of acute-phase proteins in healthy chicken (Gallus gallus) tissues

Marques

Nordio

Lecchi

et al. 2017

Veterinary Immunology and Immunopathology

View full text Add to dashboard Cite

Acute phase proteins (APP) are plasma proteins that can modify their expression in response to inflammation caused by tissue injury, infections, immunological disorders or stress. Although APP are produced mainly in liver, extrahepatic production has also been described. As a prerequisite to get insight the expression of APP in chicken during diseases, this study investigated the presence of five APP, including alpha1-acid glycoprotein (AGP), Serum Amyloid A (SAA), PIT54, C-Reactive protein (CRP) and Ovotransferrin (OVT) in twenty tissues collected from healthy chicken (Gallus gallus) by quantitative Real Time PCR and immunohistochemistry. As expected, APP gene abundance was higher in liver compared with other tissues. The mRNA coding for CRP, OVT and SAA was detected in all analyzed tissues with a higher expression in gastrointestinal tract, respiratory and lymphatic samples. SAA expression was particularly high in cecal tonsil, lung, spleen and Meckel's diverticulum, whereas OVT in lung, bursa of Fabricius and pancreas. AGP and PIT54 mRNA expression were detected in all tissues but at negligible levels. Immunohistochemical expression of AGP and OVT was variably detected in different organs, being identified in endothelium of every tissue. Positive cells were present in the epithelium of the mucosal layer of gastrointestinal tract and kidney. Lung and central nervous system stained for both proteins. No positive staining was detected in lymphoid tissues and muscle. These results suggest that most tissues can express different amount of APP even in healthy conditions and are therefore capable to mount a local acute phase reaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Widespread extrahepatic expression of acute-phase proteins in healthy chicken (Gallus gallus) tissues

Marques

Nordio

Lecchi

et al. 2017

Veterinary Immunology and Immunopathology

View full text Add to dashboard Cite

show abstract

“…A variety of other molecules are markers of systemic inflammation; these include C‐reactive protein, serum amyloid A and fibrinogen (e.g. Bickel et al ., ; Çetinkaya et al ., ; Davalos & Akassoglou, ; De Buck et al ., ; deRosset & Strutz, ; Hesselink, Aarden & Swaak, ; Kaptoge et al ., ; Ridker & Silvertown, ; Song et al ., ; Yildirim, Hur & Kokturk, ) – interestingly all correlate inversely with socioeconomic status (Jousilahti et al ., ). The role of ferritin, another ‘acute‐phase protein’ synthesised in response to infection/inflammation, has been discussed in detail elsewhere (Kell & Pretorius, ).…”

Section: Step 5: Induction By Lps and Lta Of Inflammatory Cytokinesmentioning

confidence: 99%

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

Kell

2018

Biological Reviews

108

View full text Add to dashboard Cite

Since the successful conquest of many acute, communicable (infectious) diseases through the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and progressive in nature, and are all accompanied by inflammation. These diseases include neurodegenerative (e.g. Alzheimer's, Parkinson's), vascular (e.g. atherosclerosis, pre‐eclampsia, type 2 diabetes) and autoimmune (e.g. rheumatoid arthritis and multiple sclerosis) diseases that may appear to have little in common. In fact they all share significant features, in particular chronic inflammation and its attendant inflammatory cytokines. Such effects do not happen without underlying and initially ‘external’ causes, and it is of interest to seek these causes. Taking a systems approach, we argue that these causes include (i) stress‐induced iron dysregulation, and (ii) its ability to awaken dormant, non‐replicating microbes with which the host has become infected. Other external causes may be dietary. Such microbes are capable of shedding small, but functionally significant amounts of highly inflammagenic molecules such as lipopolysaccharide and lipoteichoic acid. Sequelae include significant coagulopathies, not least the recently discovered amyloidogenic clotting of blood, leading to cell death and the release of further inflammagens. The extensive evidence discussed here implies, as was found with ulcers, that almost all chronic, infectious diseases do in fact harbour a microbial component. What differs is simply the microbes and the anatomical location from and at which they exert damage. This analysis offers novel avenues for diagnosis and treatment.

show abstract

“…Like CRP, serum amyloid A (SAA) is an acute phase reactant synthesized by the liver in response to inflammation [52]. SAA is increased in obesity [53, 54], and obesity-associated complications including atherosclerosis [55, 56].…”

Section: The Impact Of Bariatric Surgery On Diabetogenic Inflammamentioning

confidence: 99%

The impact of bariatric surgery on inflammation: quenching the fire of obesity?

Hafida

Mirshahi²,

Nikolajczyk

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Structured Abstract Purpose of the review Numerous lines of evidence support the likelihood that inflammation drives the transition from obese/metabolically healthy to obese/type 2 diabetes (T2D). Given the temporal flexibility of inflammation in obesity-associated T2D, investigators have hypothesized that a precipitous drop in diabetogenic cytokines is critical for rapid “T2D remission” following surgery but prior to significant weight loss. We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including weight loss and improved glycemic control. Recent Findings A 2016 indication for bariatric surgery to treat T2D integrates the large body of data showing short-term metabolic improvement. Parameters that account for improved glycemic control prior to significant weight loss, T2D recidivism over the long term, or failure of surgery to remit T2D in some patients are incompletely understood. Summary We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including improved glycemic control. We brainstorm future research directions that may improve surgical results.

show abstract

The cytokine-serum amyloid A-chemokine network

Cited by 110 publications

References 140 publications

Widespread extrahepatic expression of acute-phase proteins in healthy chicken (Gallus gallus) tissues

Widespread extrahepatic expression of acute-phase proteins in healthy chicken (Gallus gallus) tissues

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

The impact of bariatric surgery on inflammation: quenching the fire of obesity?

Contact Info

Product

Resources

About