The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris)

Medeiros, Helder Henrique Alves de; Santana, Melquisedec Abiaré Dantas de; Leite, Mariana Dias; Aquino, Luísa Alves Pereira de; Barros, Marília A. S.; Galvão, Nayana Tânia; Ladd, Fernando Vagner Lobo; Cavalcante, Judney Cley; Costa, Miriam S.M.O.; Nascimento, Expedito Silva do

doi:10.1016/j.neures.2016.06.005

Cited by 5 publications

(15 citation statements)

References 39 publications

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“…Hardman et al [31] showed that rat's SNCV is relatively smaller than in primates. These results have been recently confirmed in studies on a mouse [23], rock cavy [11] and bat [51]. With regard to these many reports, one of the possible explanations of our results is that the Marsupial's striatonigral dopaminergic system has simpler organisation.…”

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9supporting

confidence: 85%

“…Morphological features of the dopaminergic SN neurons are generally comparable and similar to those described previously in other species, especially SNCL [23,32,37,44,51], which suggests high evolutionary conservatism of this tier. In the SN, the TH-positive neurons with largest somas are located in the SNC, which corresponds to results of other studies [23,37,51]. Surprisingly, differences were also noted in the medial tier of SN in the mouse and bat dopaminergic neurons in the SNCM are relatively small, whereas we found mainly large cells.…”

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9supporting

confidence: 83%

“…Other studies [32] describing connections of midbrain dopaminergic neurons of another marsupial species (North American Dydelphis opossum) also confirmed that although the general organisation of midbrain neurons in the opossum is similar to the placental mammals, it is clear that differences exist. Furthermore, we could not recognise TH cell group named the "tail" of the SNC (tSN) that was reported in some species [12,51,55]. Morphological features of the dopaminergic SN neurons are generally comparable and similar to those described previously in other species, especially SNCL [23,32,37,44,51], which suggests high evolutionary conservatism of this tier.…”

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9mentioning

confidence: 51%

“…Furthermore, we could not recognise TH cell group named the "tail" of the SNC (tSN) that was reported in some species [12,51,55]. Morphological features of the dopaminergic SN neurons are generally comparable and similar to those described previously in other species, especially SNCL [23,32,37,44,51], which suggests high evolutionary conservatism of this tier. In the SN, the TH-positive neurons with largest somas are located in the SNC, which corresponds to results of other studies [23,37,51].…”

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9mentioning

confidence: 51%

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Organisation of the dopamine neuronal subsets within midbrain of the feathertail glider (Acrobates pygmaeus, Acrobatidae, Marsupialia)

et al. 2017

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The Marsupial feathertail glider has a unique set of morphological, anatomical and behavioural features that make it a promising model for study of primate evolution. Among them it has many locomotor adaptations to arboreal life, such as diagonal gait of movements, gliding, fast climbing and running along branches. These ecological and behavioural specialisations could result in differences in anatomy of the brain systems involved in their integration. It is well acknowledged that dopaminergic neurons are involved in motor control, motivation and cognition. Due to the fact that there are no data on morphological organisation of dopaminergic system in the midbrain of this species, we decided to investigate it using immunohistochemical and quantitative methods. Our study showed that the general distribution and characteristics of the dopaminergic cells within midbrain nuclei of the pygmy acrobat is similar to that in other species, but it lack the substantia nigra compact part - ventral tier and "tail" of the substantia nigra subnuclei. This study provides the first description of the dopaminergic cells and nuclei in the midbrain of the feathertail glider and we hope it will start interest in the neurobiology of this species.

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Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9supporting

confidence: 85%

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9supporting

confidence: 83%

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9mentioning

confidence: 51%

Section: Simpler Anatomical Organisation Of the Acrobates Pygmaeus A9mentioning

confidence: 51%

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Organisation of the dopamine neuronal subsets within midbrain of the feathertail glider (Acrobates pygmaeus, Acrobatidae, Marsupialia)

et al. 2017

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“…Upon activation, Nurr1 translocates to the nucleus, where it binds to the promoter region and activates the transcription of TH (38). TH is a marker for dopaminergic neurons and a rate limiting enzyme in the synthesis of dopamine (39)(40)(41). TH is only expressed in mature dopaminergic neurons, when enzymes and transporters specific for dopaminergic neurons are fully expressed and functional.…”

Section: Discussionmentioning

confidence: 99%

Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation

Huang

et al. 2017

Molecular Medicine Reports

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Paraquat (PQ) and maneb (MB) are widely used herbicides. Wingless (Wnt) proteins serve a role in the development and differentiation of dopaminergic neurons. Previous studies demonstrated that combined exposure to PQ and MB damages dopaminergic neurons in the midbrain. Effects of PQ and MB exposure on midbrain Wnt proteins have also been previously reported. In the present study, from the 5th day of gestation to weaning of the offspring, pregnant Sprague‑Dawley rats were administrated saline, or PQ and MB at two different doses: high, 15 mg/kg body weight PQ + 45 mg/kg body weight MB; or low, 10 mg/kg body weight PQ + 30 mg/kg body weight MB. Dopamine content in the striatum was examined by high performance liquid chromatography with a fluorescence detector and mRNA and protein expression of Wnt1, Wnt5a, nuclear receptor related factor 1 (Nurr1) and tyrosine hydroxylase (TH) in the midbrain was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting. Combined exposure to PQ and MB during development decreased mRNA and protein expression of Wnt1, TH and Nurr1 and increased expression of Wnt5a in the offspring.

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Functional neuroanatomical review of the ventral tegmental area

et al. 2019

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License: Article 25fa pilot End User Agreement This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act (Auteurswet) with explicit consent by the author. Dutch law entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' pilot project. In this pilot research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons.

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The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris)

Cited by 5 publications

References 39 publications

Organisation of the dopamine neuronal subsets within midbrain of the feathertail glider (Acrobates pygmaeus, Acrobatidae, Marsupialia)

Organisation of the dopamine neuronal subsets within midbrain of the feathertail glider (Acrobates pygmaeus, Acrobatidae, Marsupialia)

Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation

Functional neuroanatomical review of the ventral tegmental area

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