Abstract. This article is about the weak 16-th Hilbert problem, i.e. we analyze how many limit cycles can bifurcate from the periodic orbits of a given polynomial differential center when it is perturbed inside a class of polynomial differential systems. More precisely, we consider the uniform isochronous centerṡof degree 2n+3 and we perturb them inside the class of all polynomial differential systems of degree 2n + 3. For n = 0, 1 we provide the maximum number of limit cycles, 3 and 8 respectively, that can bifurcate from the periodic orbits of these centers using averaging theory of first order, or equivalently Abelian integrals. For n = 2 we show that at least 12 limit cycles can bifurcate from the periodic orbits of the center.