The Cyclical Variation in the Percentage of Ciliated Cells in the Normal Human Endometrium

Masterton, R.G.; Armstrong, E M; More, I. A. R.

doi:10.1530/jrf.0.0420537

Cited by 52 publications

(20 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The best-documented studies of the human endometrial ultrastructure are related to special features, such as cyclic variation in endometrial ciliated cells (Masterton et al, 1975), the nucleolar channel system of human glandular cells (Terzakis, 1965;Kohorn et al, 1970Kohorn et al, ,1972More et al, 1974More et al, , 1975More and McSeveney, 19801, giant lysosomes (Cavazos and Lucas, 19701, and giant basal mitochondria (Nilsson, 1962;Armstrong et al, 1973).…”

Section: Limitations Of Ultrastructural Analyses Of Primate Endometrimentioning

confidence: 99%

Ultrastructural epithelial zonation of the primate endometrium (rhesus monkey)

Kaiserman-Abramof

Padykula

1989

Am. J. Anat.

View full text Add to dashboard Cite

The uterine endometrium of menstruating primates (rhesus monkey, human) consists of a germinal basalis that regenerates a transient functionalis during each menstrual cycle. The endometrium is further subdivided into 4 zones that differ histologically and in epithelial mitotic rate along the longitudinal axes of the uterine glands and microvasculature (Bartelmez et al: Contrib. Embryol. Carnegie Inst., 34:99-146, 1951; Bartelmez: Am. J. Obstet. Gynecol., 74:931-955, 1957; Padykula et al.: Biol. Reprod., 32:1103-1118, 1118, 1984; Biol. Reprod., in press, 1988). The zones are defined as follows: functionalis I, luminal epithelium; functionalis II (upper straight gland segments); basalis III (middle gland segments), and basalis IV (bottoms of the glands). The surrounding stroma and microvasculature also differ zonally. Ultrastructural epithelial differences are evident among the 4 zones during 3 distinct functional states during natural menstrual cycles and after ovariectomy: 1) basal level after ovariectomy and 2) estrogen dominance and 3) progesterone dominance. Zonal structural differences persist at a minimal level of differentiation after ovariectomy and thus zonation is an inherent property. During estrogen dominance, distinctive ultrastructural differences are evident among the 4 zones, such as epithelial cell heterogeneity in functionalis I and homogeneity in functionalis II. Also a distinctive glandular cell type occurs in basalis III and IV that is recognized by a highly irregular cisternal rough endoplasmic reticulum that permeates the cytoplasm. During progesterone dominance, ultrastructural differences exist among the 4 zones except for similarity between the epithelial cells of functionalis II and basalis III. Postovulatory epithelial cells of functionalis I and II and basalis III become postmitotic via progesterone inhibition but intracellular differentiation continues progressively. Postovulatory epithelial mitotic activity in basalis IV escapes progesterone inhibition as the [3H]thymidine labeling index continues to increase from 1 to 12% during the menstrual cycle (Padykula et al.: Reprod., 30(Suppl.1):92 (Abstr. 123), 1984). This post-ovulatory proliferation coupled with progressive differentiation in basalis IV may represent a stem-progenitor set of cells for postmenstrual endometrial regeneration or alternatively for creation of the maternal placenta.

show abstract

Section: Limitations Of Ultrastructural Analyses Of Primate Endometrimentioning

confidence: 99%

Ultrastructural epithelial zonation of the primate endometrium (rhesus monkey)

Kaiserman-Abramof

Padykula

1989

Am. J. Anat.

View full text Add to dashboard Cite

show abstract

“…Johannisson & Nilsson (1972) (Fleming et al, 1968;Schueller, 1968;Johannisson & Nilsson, 1972;Ferenczy et al, 1972). Our work indicates that the reported reduction in numbers in the secretory phase (Masterton et al, 1975) is only an apparent loss due to secretory activity, a previously unreported role for ciliated cells.…”

Section: Resultsmentioning

confidence: 49%

“…The ultrastructure of the ciliated cells has been largely ignored, however, in favour of its more numerous counterpart-the glandular cell (Bordi et al, 1959;Armstrong et al, 1973). The cyclical variations in frequency of the ciliated cell have been determined (Masterton et al, 1975), but their function and fate are unknown. The present work was carried out to investigate the ultrastructure of the endo¬ metrial ciliated cell.…”

Section: Introductionmentioning

confidence: 99%

The Fine Structure of the Human Endometrial Ciliated Cell

More¹,

Masterton²

1975

Reproduction

Self Cite

View full text Add to dashboard Cite

“…Furthermore, up to 20% of normal endometrial cells may bear cilia during days 8-22 of the menstrual cycle. 27 Ciliation is unhelpful in the diagnosis of endometriosis, nor should its presence exclude a malignant process. 28 Interestingly, tubal or tubo-endometrioid metaplasia accompanied SCVE in four of the six cervices which were examined histologically ( Table I).…”

Section: Discussionmentioning

confidence: 99%