The Cycle of Kinetochore-Negative Micronuclei and Chromosome Fragments Occurred in Mitosis of Hela Cells

Abstract

Objective: Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. According to the presence of kinetochores or not, MNi are further classified into kinetochore-negative MNi (K−MNi) and kinetochore-positive MNi (K+MNi), which show the different mechanisms of micronucleus formation. However, the differences in fates of K−MNi and K+MNi have not been completely addressed. The present study aims to address these questions.