The CyberKnife radiosurgery system for lung cancer

Nuyttens, J.; Pol, M. van de

doi:10.1586/erd.12.35

Cited by 56 publications

(41 citation statements)

References 45 publications

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“…The safety of SRS on pulmonary metastasis from OS may be contributed to not only the technical improvements but also the unique metastatic characteristics of OS, which are usually small lesions and often located at peripheral parts of the lung. For SRS, smaller lesions at peripheral site of the lung without association with central airways means less possibility of lung injury (22,23), which implies that pulmonary metastasis from OS is a potentially good candidate for SRS.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma

Tang

Lin

et al. 2014

International Journal of Oncology

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Stereotactic radiosurgery (SRS), such as body gamma knife, was reported to achieve excellent rates of local disease control with limited toxicity in many cases of primary or secondary pulmonary tumor, except osteosarcoma. To confirm the value of SRS in pulmonary metastases from osteosarcoma, we reviewed the experience from our institution (Department of Oncology, Affiliated Sixth People’s Hospital, Shanghai) and compared the efficiency of SRS with that of surgical resection. From January 2005 to December 2012, we carried out a retrospective investigation of 58 patients (age, 8–59 years; mean, 25.2 years) who were diagnosed with non-metastatic osteosarcoma of the extremity and later developed pulmonary metastasis during the period of adjuvant chemotherapy or follow-up. Among them, 27 patients were treated by SRS using the body gamma-knife system. A total dose of 50 Gy was delivered at 5 Gy/fraction to the 50% isodose line covering the planning target volume, whereas a total dose of 70 Gy was delivered at 7 Gy/fraction to the gross target volume. The other 31 patients were treated by surgical resection. Two-year progression-free survival rate, two-year survival rate, median time of PRPFS (post-relapse progress-free survival) and PROS (post-relapse overall survival) in SRS group were parallel to that in surgical group. All 27 patients tolerated gamma knife radiosurgery well while only 9 patients had grades 1–2 pneumonitis. We believe SRS, compared with surgical resection, is effective and safe in treating pulmonary metastasis from osteosarcoma, especially for those patients who were medically unfit for a resection or who refused surgery.

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Section: Discussionmentioning

confidence: 99%

Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma

Tang

Lin

et al. 2014

International Journal of Oncology

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“…The target locating system (TLS) is composed of two ceiling‐mounted diagnostic X‐ray sources paired with amorphous silicon detectors, and acquires live digital radiographic images of the target, bony anatomy, and fiducial markers. The Synchrony system enables three‐dimensional real‐time tracking of tumors that move with respiration (18) . The system uses infrared markers that are continually tracked by three flash‐point cameras, which generate 26 images per second.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of tracking accuracy of the CyberKnife system using a webcam and printed calibrated grid

Sumida

Shiomi

Higashinaka³

et al. 2016

J Applied Clin Med Phys

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Tracking accuracy for the CyberKnife's Synchrony system is commonly evaluated using a film‐based verification method. We have evaluated a verification system that uses a webcam and a printed calibrated grid to verify tracking accuracy over three different motion patterns. A box with an attached printed calibrated grid and four fiducial markers was attached to the motion phantom. A target marker was positioned at the grid's center. The box was set up using the other three markers. Target tracking accuracy was evaluated under three conditions: 1) stationary; 2) sinusoidal motion with different amplitudes of 5, 10, 15, and 20 mm for the same cycle of 4 s and different cycles of 2, 4, 6, and 8 s with the same amplitude of 15 mm; and 3) irregular breathing patterns in six human volunteers breathing normally. Infrared markers were placed on the volunteers’ abdomens, and their trajectories were used to simulate the target motion. All tests were performed with one‐dimensional motion in craniocaudal direction. The webcam captured the grid's motion and a laser beam was used to simulate the CyberKnife's beam. Tracking error was defined as the difference between the grid's center and the laser beam. With a stationary target, mean tracking error was measured at 0.4 mm. For sinusoidal motion, tracking error was less than 2 mm for any amplitude and breathing cycle. For the volunteers’ breathing patterns, the mean tracking error range was 0.78‐1.67 mm. Therefore, accurate lesion targeting requires individual quality assurance for each patient.PACS number(s): 87.55.D‐, 87.55.km, 87.55.Qr, 87.56.Fc

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“…All patients were treated with real-time tumor tracking using the CyberKnife [10]. The technique has been described previously [11].…”

Section: Methodsmentioning

confidence: 99%

Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer

et al. 2015

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PurposeTo determine the long-term impact of stereotactic radiotherapy (SRT) on the quality of life (QoL) of inoperable patients with early-stage non-small cell lung cancer (NSCLC).Methods and materialsFrom January 2006 to February 2008, 39 patients with pathologically confirmed T1-2N0M0 NSCLC were treated with SRT. QoL, overall survival and local tumor control were assessed. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 and the lung cancer-specific questionnaire QLQ-LC13 were used to investigate changes in QoL. Assessments were done before treatment, at 3 weeks, every 2–3 months during the first two years, and then every 6 months until 5 years after the treatment or death or progressive disease. The median follow up was 38 months.ResultsDuring the 5 years after treatment with SRT for stage I NSCLC, the level of QoL was maintained: There was a slow decline (slope: −0.015) of the global health status over the 5 years (p < 0.0001). The physical functioning and the role functioning improved slowly (slope: 0.006 and 0.004, resp.) over the years and this was also significant (p < 0.0001). The emotional functioning (EF) improved significantly at 1 year compared to the baseline. Two years after the treatment dyspnea slowly increased (slope: 0.005, p = 0.006). The actuarial overall survival was 62% at 2 years and 31% at 5-years.ConclusionQoL was maintained 5 years after SRT for stage I NSCLC and EF improved significantly. Dyspnea slowly increased 2 years after the treatment.

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The CyberKnife radiosurgery system for lung cancer

Cited by 56 publications

References 45 publications

Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma

Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma

Evaluation of tracking accuracy of the CyberKnife system using a webcam and printed calibrated grid

Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer

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