The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis

Aydemir, Cumhur; Aydemir, Hande; Köktürk, Fürüzan; Külah, Canan; Mungan, Ayca Gorkem

doi:10.1186/s12887-018-1236-2

Cited by 44 publications

(33 citation statements)

References 30 publications

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“…At this cut-off, the sensitivity, specificity, PPV, and NPV were 76.5%, 98.2%, 94.9%, and 90.5%, respectively. For the diagnosis of clinical sepsis, with CRP cut-off of 2.6 mg/L, the sensitivity, specificity, PPV, and NPV were 73.6%, 83.0%, 67.2%, and 86.9% respectively 26. In our study, we found the cut-off values of CRP in suspected EOS and proven EOS 4.5, 7.2 mg/L, respectively.…”

Section: Discussionsupporting

confidence: 47%

Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early Onset Neonatal Sepsis

Arcagök

Karabulut²

2019

Mediterr J Hematol Infect Dis

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Introduction Neonatal sepsis (NS) is a common systemic disease that causes morbidity and mortality in newborns. But there is no ideal biomarker that can be used in the early diagnosis of NS. In recent studies, platelet width to lymphocyte ratio (PLR) have been reported to play a critical role in the inflammatory process. In this study, we aimed to contribute to the research about whether or not PLR can be used in the early diagnosis of NS. Methods This retrospective cohort study was conducted among the newborns whose born in İzmir Buca Maternity and Pediatric Hospital between March 2015-February 2016. During these twelve months, 611 neonates with EOS were admitted to our neonatal intensive care unit. One hundred and forty-nine neonates with suspected EOS, 67 neonates with proven EOS and 92 healty neonates were enrolled in the study. Results Platelet width lymphocyte (LPR) values of the groups were calculated 56.5 ± 17.8 vs 62.4± 14.9 vs 15.3 ± 2.1 respectively. PLR values of suspected or proven EOS group was significantly higher than the control group. PLR has AUC 0.89 to 0.93, cutoff value of 39.5 to 57.7, sensitivity of 88.9% to 91.3% and specifity of 94.7% to 97.6%, positive predictive value of 94.3% to 97.4%, and negative predictive value of 88.6% to 91.8% in suspected and proven sepsis diagnosis. Conclusion Based on our results suggest that PLR can be used as a biomarker predictive of EOS.

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Section: Discussionsupporting

confidence: 47%

Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early Onset Neonatal Sepsis

Arcagök

Karabulut²

2019

Mediterr J Hematol Infect Dis

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“…La incidencia de proporción entre los que desarrollaron sepsis fue de 0,44 (24/33) con una significancia estadística dada por un valor de p 0,000 (Tabla 4). Se utilizó para este análisis un valor positivo ≥ 10 mg/L; referenciando que es el valor óptimo con mayor utilidad diagnóstica según la literatura médica actual 21 . El riesgo relativo (RR) para los pacientes con PCR inicial elevada fue de 7,062 (IC 95% 3,5-14,2).…”

Section: Información Materna Control Prenatal Y Atención Del Partounclassified

Utilidad de la proteína C-reactiva en la sepsis neonatal temprana

Ávila

Villegas²

2021

Rev. chil. infectol.

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Introducción: La baja sensibilidad y especificidad de las ayudas diagnósticas y el bajo aislamiento en los cultivos dificulta el reconocimiento de la sepsis bacteriana de inicio temprano en neonatos. Objetivo: Determinar la validez diagnóstica de la de la proteína C reactiva (PCR) en la sepsis en la sepsis neonatal temprana. Método: Se evaluó el papel de la PCR en el diagnóstico de sepsis neonatal temprana. Las concentraciones se midieron a las 12 y 48 h de vida en pacientes con sospecha de sepsis. Al evaluar la sensibilidad y especificidad de la PCR, se utilizó el resultado de manera cuantitativa y mediante una curva ROC no paramétrica se estimó sensibilidad y especificidad, razones de verosimilitud y porcentaje de clasificación correcta para cada punto de corte posible. Resultados: El estudio incluyó 198 pacientes. La sensibilidad, especificidad, valor predictor positivo (VPP), valor predictor negativo (VPN), índice de probabilidad positiva e índice de probabilidad negativa de la PCR fue de 72,2 -82,4 -45,2 -93,7 -4,1 y 0,3, respectivamente con área bajo la curva de 0,78. Conclusiones: La PCR es particularmente útil para descartar una infección. Dos PCR seriadas negativas en ausencia de expresión clínica y de hemocultivos positivos tienen un alto VPN y un índice de probabilidad negativa a favor de excluir la infección con una alta certeza y/o de descontinuar la terapia antibiótica.Palabras clave: sepsis neonatal de inicio temprano, proteína Creactiva.

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“…In newborns, the source of the pathogen may be an in utero infection, maternal flora infection or postpartum infection from the hospital or community ( 2 ). Neonatal sepsis (NS) is a leading cause of morbidity and mortality in newborns ( 3 ), and it may be categorized as early-onset NS (EOS) or late-onset NS (LOS) ( 4 ). The morbidity and mortality of NS have been reduced due to progress made in neonatal care ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes

Wang

Han

2021

Exp Ther Med

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Neonatal sepsis (NS) remains a global problem. In the present study, abnormal expression of microRNA-1184 (miR-1184) was detected in neonates with NS and it was endeavored to investigate the diagnostic value of miR-1184, as well as its regulatory role in lipopolysaccharide (LPS)-induced inflammatory response in vitro. Furthermore, the correlation between interleukin-16 (IL-16) and miR-1184 was investigated to elucidate the pathological mechanisms of NS development. Reverse transcription-quantitative PCR was used to detect the expression of miR-1184. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic value of miR-1184 in NS. Furthermore, a sepsis cell model was established by using LPS-induced monocytes to explore the effect of miR-1184 on the inflammatory response. The levels of inflammatory cytokines were determined by ELISA. A luciferase reporter assay was used to investigate the direct targeting interaction between miR-1184 and IL-16. The results indicated that the serum levels of miR-1184 in neonates with sepsis were decreased and miR-1184 had a high diagnostic value when differentiating NS from respiratory conditions in neonates. In vitro, the expression of miR-1184 in monocytes was inhibited by LPS and overexpression of miR-1184 reversed the effect of LPS to stimulate the inflammatory response. IL-16 was demonstrated to be a target of miR-1184 and a negative correlation between them was identified in patients with NS. The inflammatory response inhibited by miR-1184 mimics was enhanced by overexpression of IL-16 in LPS-induced monocytes. In conclusion, decreased levels of serum miR-1184 may be a potential diagnostic biomarker for NS. In addition, miR-1184 inhibited the LPS-induced inflammatory response by targeting IL-16 in monocytes, suggesting that the miR-1184/IL-16 axis may be a potential therapeutic target for NS.

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The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis

Cited by 44 publications

References 30 publications

Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early Onset Neonatal Sepsis

Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early Onset Neonatal Sepsis

Utilidad de la proteína C-reactiva en la sepsis neonatal temprana

Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes

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