The Current Status of Tissue-Engineered Vascular Grafts

Jaspan, Vita; Hines, George L.

doi:10.1097/crd.0000000000000060

Cited by 14 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous research demonstrated an excellent performance of these grafts upon the implantation into rat abdominal aortas; however, the rat model may not be optimal for testing biodegradable vascular grafts due to rapid endothelization observed in these animals. Thus, we aimed to reinforce our findings using a sheep model, which is considered more aggressive than rat in terms of thrombosis and calcification, thus being more optimal for in vivo testing of cardiovascular implants [18][19][20].…”

Section: Discussionmentioning

confidence: 86%

A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep

et al. 2020

View full text Add to dashboard Cite

The development of novel biodegradable vascular grafts of a small diameter (<6 mm) is an unmet clinical need for patients requiring arterial replacement. Here we performed a pre-clinical study of new small-caliber biodegradable vascular grafts using a sheep model of carotid artery implantation. The 4 mm diameter vascular grafts were manufactured using a mix of polyhydroxybutyrate/valerate and polycaprolactone supplemented with growth factors VEGF, bFGF and SDF-1α (PHBV/PCL-GFmix) and additionally modified by a polymer hydrogel coating with incorporation of drugs heparin and iloprost (PHBV/PCL-GFmixHep/Ilo). Animals with carotid artery autograft implantation and those implanted with clinically used GORE-TEX® grafts were used as control groups. We observed that 24 h following surgery, animals with carotid artery autograft implantation showed 87.5% patency, while all the PHBV/PCL-GFmix and GORE-TEX® grafts displayed thrombosis. PHBV/PCL-GFmixHep/Ilo grafts demonstrated 62.5% patency 24 h following surgery and it had remained at 50% 1 year post-operation. All the PHBV/PCL grafts completely degraded less than 1 year following surgery and were replaced by de novo vasculature without evidence of calcification. On the other hand, GORE-TEX® grafts displayed substantial amounts of calcium deposits throughout graft tissues. Thus, here we report a potential clinical usefulness of PHBV/PCL grafts upon their additional modification by growth factors and drugs to promote endothelialization and reduce thrombogenicity.

show abstract

Section: Discussionmentioning

confidence: 86%

A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Until there is more experience with biological vascular grafts, the alternative to a saphenous vein is a PTFE interposition graft. 6 7 …”

Section: Discussionmentioning

confidence: 99%

Prosthetic graft infection after vascular trauma

Tchorz

Rozycki

Feliciano

2020

Trauma Surg Acute Care Open

View full text Add to dashboard Cite

“…Подобные протезы успешно применяют в реконструктивной хирургии сосудов с диаметром более 6 мм. В случае с поврежденным сосудом меньшего диаметра, особенностью гемодинамики которого является более низкая скорость кровотока, биостабильные графты становятся непригодными вследствие стремительной гиперплазии неоинтимы и тромбоза [15][16][17].…”

Section: искусственные трансплантатыunclassified

Biodegradable small-diameter vascular graft: types of modification with bioactive molecules and RGD peptides

Senokosova

Кривкина

Антонова

et al. 2020

RJTAO

View full text Add to dashboard Cite

The need for small-diameter grafts for replacing the damaged area of the blood pool is still very high. These grafts are very popular for coronary artery bypass grafting. Polymeric synthetic grafts are an alternative to autografts. A promising area of tissue engineering is the creation of a biodegradable graft. It can serve as the basis for de novo generation of vascular tissue directly in the patient’s body. Optimization of the polymer composition of products has led to improved physicomechanical and biocompatible properties of the products. However, the improvements are still far from needed. One of the decisive factors in the reliability of a small-diameter vascular graft is the early formation of endothelial lining on its inner surface, which can provide atrombogenic effect and full lumen of the future newly formed vessel. To achieve this goal, grafts are modified by incorporating bioactive molecules or functionally active peptide sequences into the polymer composition or immobilizing on its inner surface. Peptide sequences include cell adhesion site – arginine-glycine-aspartic acid (RGD peptide). This sequence is present in most extracellular matrix proteins and has a tropism for integrin receptors of endothelial cells. Many studies have shown that imitation of the functional activity of the natural extracellular matrix can promote spontaneous endothelization of the inner surface of a vascular graft. Moreover, configuration of the RGD peptide determines the survival and differentiation of endothelial cells. The linker through which the peptide is crosslinked to the polymer surface determines the bioavailability of the RGD peptide for endothelial cells.

show abstract

The Current Status of Tissue-Engineered Vascular Grafts

Cited by 14 publications

References 28 publications

A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep

A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep

Prosthetic graft infection after vascular trauma

Biodegradable small-diameter vascular graft: types of modification with bioactive molecules and RGD peptides

Contact Info

Product

Resources

About