The current status of human laryngeal transplantation in 2017: A state of the field review

Krishnan, Giri; Du, Charles; Fishman, Jonathan; Foreman, Andrew; Lott, David G.; Farwell, D. Gregory; Belafsky, Peter C.; Krishnan, Suren; Birchall, Martin A.

doi:10.1002/lary.26503

Cited by 27 publications

(10 citation statements)

References 58 publications

(101 reference statements)

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“…Larynx transplantation is currently mainly a theoretical option that can only be applied in exceptional cases and that is not suitable for reconstruction after tumor surgery. However, it has been described twice in the literature 93 94 . To create an artificial larynx, the production of various tissues, including cartilage, laryngeal muscles, and laryngeal mucosa, must be coordinated.…”

Section: Regenerative Procedures In Otorhinolaryngology – State-ofmentioning

confidence: 99%

“…Hamilton und Birchall gehen in einer aktuellen Übersicht davon aus, dass die Therapie des Larynxkarzinoms in den kommenden 10 Jahren durch die Entwicklungen im Bereich der Larynxregeneration entscheidend beeinflusst werden wird 92 . Die Larynxtransplantation ist eine derzeit v. a. theoretische Option, die aufgrund der notwendigen Immunsuppression nur in Ausnahmefällen und nicht für die Rekonstruktion nach Tumorchirurgie in Betracht kommt, aber auch bereits 2-mal in der Literatur beschrieben wurde 93 94 . Für die Herstellung eines artifiziellen Larynx ist die Herstellung so unterschiedlicher Gewebe wie des knorpeligen Gerüsts, der laryngealen Muskulatur und der laryngealen Schleimhaut in koordinierter Weise erforderlich.…”

Section: 22 Larynxunclassified

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Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

Rotter

Zenobi‐Wong

2018

Laryngo-Rhino-Otol

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ZusammenfassungDie Regeneration als therapeutisches Prinzip und damit die Regenerative Medizin ist ein vielversprechender Ansatz künftig die therapeutischen Optionen der Hals-Nasen-Ohrenheilkunde um eine weitere Dimension zu erweitern. Während heute rekonstruktive chirurgische Verfahren, Medikamente und Prothesen wie bspw. das Cochlea Implantat die Funktionen defekter Gewebe im Kopf-Hals-Bereich ersetzen, sollen durch die Regenerative Medizin die defekten Gewebe und deren Funktion selbst wiederhergestellt werden. In dieser Übersichtsarbeit werden neue Entwicklungen wie das 3D-Bioprinting und dezellularisierte, natürliche Biomaterialien für regenerative Ansätze vorgestellt und durch eine Zusammenstellung aktueller präklinischer und klinischer Studien im Bereich der Regenerativen Medizin in der Hals-Nasen-Ohrenheilkunde ergänzt.

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Section: Regenerative Procedures In Otorhinolaryngology – State-ofmentioning

confidence: 99%

Section: 22 Larynxunclassified

Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

Rotter

Zenobi‐Wong

2018

Laryngo-Rhino-Otol

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“…Over the past twenty years, notable surgical developments have advanced the field of vascularized composite tissue allotransplantation (VCA), making it a viable treatment for patients with major defects involving multiple layers of tissue including hand, face, penis, and laryngeal transplantation, among others (1)(2)(3)(4)(5). As in solid organ transplantation, VCA must overcome a significant immune barrier to provide meaningful, long-term benefit.…”

Section: Introductionmentioning

confidence: 99%

Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

et al. 2021

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Over the past twenty years, significant technical strides have been made in the area of vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation, the allogeneic immune response remains a significant barrier to long-term VCA survival and function. Strategies to overcome acute and chronic rejection, minimize immunosuppression and prolong VCA survival have important clinical implications. Historically, large animals have provided a valuable model for testing the clinical translatability of immune modulating approaches in transplantation, including tolerance induction, co-stimulation blockade, cellular therapies, and ex vivo perfusion. Recently, significant advancements have been made in these arenas utilizing large animal VCA models. In this comprehensive review, we highlight recent immune strategies undertaken to improve VCA outcomes with a focus on relevant preclinical large animal models.

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“…Electro larynxes were first introduced in the 1940s 4 . In that period, oesophageal speech was being promoted as the best option in speech.…”

Section: Introductionmentioning

confidence: 99%

Motor integrated electro larynx; a novel, less expensive electro larynx

Jayasena¹,

Dayaratne²,

Bandara³

2020

Ceylon J Otolaryngology

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Introduction Total laryngectomy results in a muted person. Electro larynx is one method of sound production for speech in such patients. We introduce a novel, less expensive electro larynx. Objectives To assess the usability of the novel electro larynx. Methods A new electro larynx was developed. Imbalanced motor was used as the vibrator and hence it could be operated with a 3V battery. It is made as a rechargeable device using a mobile phone charger. Fifty Sinhala and English words and 20 numbers were read by a researcher. It was listened and recorded by 5 listeners and documented. Correctly identified words and numbers were analyzed. Test was done both with and without lip reading. Results The new device could generate sound for speech. Eighty-eight percent of English and 89.2% of Sinhala words could be identified with lip reading. For numbers it was 97.6%. Conclusions Novel electro larynx could be used for effective communication in post laryngectomy patients.

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The current status of human laryngeal transplantation in 2017: A state of the field review

Cited by 27 publications

References 58 publications

Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

Motor integrated electro larynx; a novel, less expensive electro larynx

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