The current status of biodegradable stent to treat benign luminal disease

Zhang, Donghui; Yang, Kai; Chen, Ruoyu; Xiang, Yi; Yuan, Tianwen; Cheng, Ying-Sheng; Sarmento, Bruno; Cui, Wenguo

doi:10.1016/j.mattod.2017.05.002

Cited by 76 publications

(66 citation statements)

References 126 publications

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“…Complete resorption of the scaffold allows an unobstructed integrity of the vessel wall, recovery of the vasomotor function and the absence of artifacts in non-invasive imaging techniques. 2 By virtue of the numerous benefits in comparison to conventional materials, extensive research has been going into the development of such devices leading to the first FDA-approved biodegradable coronary artery stent in 2016 3 and indicating many more to come. Polycaprolactone (PCL) and its copolymers are among the most extensively used resorbable implant materials.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional coatings combining bioactive peptides and affinity-based cytokine delivery for enhanced integration of degradable vascular grafts

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Multifunctional coatings combining bioactive peptides and affinity-based cytokine delivery for enhanced integration of degradable vascular grafts

et al. 2020

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“…Actualmente, los materiales para este tipo de aplicaciones son metales permanentes tales como el cromo-cobalto, níquel, titanio y aceros inoxidables. Estos materiales son efectivos en las primeras etapas del tratamiento, pero con el tiempo pueden causar problemas secundarios como la re-oclusión del lumen del vaso sanguíneo, problema conocido como reestenosis [28,29] Adicionalmente, algunos problemas asociados a la interacción sangre-material, pueden concluir en la formación de coágulos, lo cual puede ser altamente peligroso para el paciente. Por esta razón, han emergido las formulaciones donde medicamentos anticoagulantes son inmovilizados en la superficie del implante como una solución a este problema, que termina siendo paliativa hasta que el medicamento finalmente se consuma.…”

Section: Problemas Cardiovascularesunclassified

Desarrollo de la industria de aleaciones de magnesio en Colombia - Una oportunidad

Berrio-Betancur

Echeverry‐Rendón

Correa

et al. 2017

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Magnesium and its alloys are some of the materials that have had notable growing progress in recent years. This interest in magnesium base alloys is due to both, its physical and mechanical properties, as well as the search for alternatives to less polluting materials. In order to provide an overview of the possibilities that the use of this material has in the domestic industry, this work gives a look at the basic aspects of the material and the processes of obtaining; its most promising applications and with potential to be developed in Colombia. Finally, the authors discuss their research and results on this material, seeking to be employed as inputs for the implementation of processes and products at the commercial level.Keyword: Magnesium; magnesium synthesis; magnesium applications; magnesium sustainability.Desarrollo de la industria de aleaciones de magnesio en ColombiaUna oportunidad ResumenDentro de los materiales que más avance han tenido en las últimas décadas, se encuentran el magnesio y sus aleaciones, cuyo volumen de producción mundial se ha incrementado notoriamente en los últimos años. El creciente interés en el magnesio se debe tanto a sus propiedades físicas y mecánicas como a la búsqueda de alternativas de materiales menos contaminantes. Con el objeto de proporcionar una visión general de las posibilidades que el uso de este material tiene en la industria nacional, en este trabajo se da una mirada a los aspectos básicos del material y de los procesos de obtención del mismo, así como a sus aplicaciones más promisorias y con potencial de ser desarrolladas en Colombia. Para finalizar, los autores discuten sus investigaciones y resultados acerca de este material, buscando su aprovechamiento como insumo para la implementación de procesos y productos a nivel comercial.Palabras clave: magnesio; síntesis de magnesio; aplicaciones del magnesio; sostenibilidad del magnesio.

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“…The first generation of stents, BMS, usually fabricated from stainless steel (316L), cobalt-chromium (Co-Cr) and platinum-iridium (Pt-Ir) alloys, tantalum (Ta), or nitinol (Ni-Ti) have shown numerous problems leading to tissue hyperplasia, in-stent restenosis and the necessity to explant them or to keep them as a foreign body during the whole life. These considerations pushed the development of coated stents, DES, and biodegradable stents (BDS) [3]. Providing an overview of the stent technology in the treatment of ischemic stroke, describing the commonly used stents, and defining the development trends in their fabrication technologies, Yoon et al [4] have shown the potential of coated stents, DES [5,6], and BDS for future applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Manufacturing Innovative Stents

et al. 2020

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Cardiovascular diseases are the most distributed cause of death worldwide. Stenting of arteries as a percutaneous transluminal angioplasty procedure became a promising minimally invasive therapy based on re-opening narrowed arteries by stent insertion. In order to improve and optimize this method, many research groups are focusing on designing new or improving existent stents. Since the beginning of the stent development in 1986, starting with bare-metal stents (BMS), these devices have been continuously enhanced by applying new materials, developing stent coatings based on inorganic and organic compounds including drugs, nanoparticles or biological components such as genes and cells, as well as adapting stent designs with different fabrication technologies. Drug eluting stents (DES) have been developed to overcome the main shortcomings of BMS or coated stents. Coatings are mainly applied to control biocompatibility, degradation rate, protein adsorption, and allow adequate endothelialization in order to ensure better clinical outcome of BMS, reducing restenosis and thrombosis. As coating materials (i) organic polymers: polyurethanes, poly(ε-caprolactone), styrene-b-isobutylene-b-styrene, polyhydroxybutyrates, poly(lactide-co-glycolide), and phosphoryl choline; (ii) biological components: vascular endothelial growth factor (VEGF) and anti-CD34 antibody and (iii) inorganic coatings: noble metals, wide class of oxides, nitrides, silicide and carbide, hydroxyapatite, diamond-like carbon, and others are used. DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (siro-, zotaro-, evero-, bio-, amphi-, tacro-limus), ABT-578, tyrphostin AGL-2043, genes, etc. The innovative solutions aim at overcoming the main limitations of the stent technology, such as in-stent restenosis and stent thrombosis, while maintaining the prime requirements on biocompatibility, biodegradability, and mechanical behavior. This paper provides an overview of the existing stent types, their functionality, materials, and manufacturing conditions demonstrating the still huge potential for the development of promising stent solutions.

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The current status of biodegradable stent to treat benign luminal disease

Cited by 76 publications

References 126 publications

Multifunctional coatings combining bioactive peptides and affinity-based cytokine delivery for enhanced integration of degradable vascular grafts

Multifunctional coatings combining bioactive peptides and affinity-based cytokine delivery for enhanced integration of degradable vascular grafts

Desarrollo de la industria de aleaciones de magnesio en Colombia - Una oportunidad

Recent Advances in Manufacturing Innovative Stents

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