“…In particular, it is known that the bound water plays an important role in food preservation, especially in drying technologies for foods. Many experimental works on characterizing the bound water, such as those involving nuclear magnetic resonance (NMR), [3][4][5][6][7]19,20) differential scanning calorimetry (DSC), 8,9,[20][21][22][23][24][25][26][27] dielectric measurements, [10][11][12][13][14][15]28,29) and infrared (IR) and Raman spectroscopies, have been performed. 9,26,[29][30][31] These experimental studies, together with molecular dynamic (MD) simulations [15][16][17][18] for water-containing hydrophilic molecules, have revealed the following three types of water that surrounds protein molecules: strongly bound, weakly bound, and free waters.…”