The current state of retinopathy of prematurity in India, Kenya, Mexico, Nigeria, Philippines, Romania, Thailand, and Venezuela

Bowe, Theodore; Nyamai, Lily A; Ademola-Popoola, Dupe S; Amphornphruet, Atchara; Anzures, Rachelle; Cernichiaro-Espinosa, Linda A.; Duke, Roseline; Duran, Fahir; Martínez-Castellanos, María Ana; Multani, Prabhujot Kaur; Niţulescu, C; Padhi, Tapas Ranjan; Tipsuriyaporn, Boontip; Chan, R.V. Paul; Campbell, J. Peter; Yonekawa, Yoshihiro

doi:10.5693/djo.01.2019.08.002

Cited by 54 publications

(59 citation statements)

References 30 publications

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“…The incidence of ROP varies considerably in different populations and ethnic groups, so much so that in India it fluctuates from 38 to 47%, Thailand reports prevalence between 14 and 33%, while in Mexico approximately 24% of childhood blindness occurs as a result of ROP. 16 In this study, the overall incidence of ROP in preterm infants was 33.3% (72 of 144), with 23.6% of these infants having severe ROP (stage 3) ( Tables 2 and 3 ). In a study conducted in 2010–2011 in the same city, an incidence of 19.06% was reported, 17 this increase in recent years is also evident in other Latin American countries.…”

Section: Discussionmentioning

confidence: 51%

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carranza-Mendizabal¹,

Diaz-Manrique²,

Mamani

et al. 2021

OPTH

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The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital. Patients and Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. All infants were examined according to Peruvian guidelines for screening and treatment of ROP. The association of clinical risk factors and the development of ROP was analyzed and predictive factors were determined. Results:The study subjects were 216 preterm infants of which 72 had some stage of ROP (32 stage 1; 23 stage 2 and 17 stage 3) and 144 preterm infants without ROP. The incidence of ROP in preterm infants less than 32 weeks was 60.9%, while for those weighing less than 1500 g it was 71.6%. The factors associated with ROP were gestational age below 32 weeks, birth weight below 1500 grams, neonatal sepsis, oxygen therapy, mechanical ventilation, hyaline membrane disease, bronchopulmonary dysplasia, persistence of ductus arteriosus and intraventricular hemorrhage. Exclusive breastfeeding was found to play a protective role against ROP. Binary logistic regression analysis found that only gestational age below 32 weeks (OR, 2.637; 95% CI, 1.04-6.69), weight below 1500 grams (OR, 4.377; 95% CI, 1.75-10.92), neonatal sepsis (OR, 6.517; 95% CI, 2.81-15.14), vaginal delivery (OR, 3.748; 95% CI: 1.54-9.14), and the presence of hyaline membrane disease (OR, 3.58; 95% CI,) are predictors of ROP. Conclusion:The incidence of ROP among very low birth weight infants was 71.6%. Infants with weight below 1500 grams, neonatal sepsis, presence of hyaline membrane disease whose mother had vaginal delivery are at risk for the development of ROP. Thus, preventing premature births and encouraging exclusive breastfeeding are two main ways to prevent ROP.

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Section: Discussionmentioning

confidence: 51%

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carranza-Mendizabal¹,

Diaz-Manrique²,

Mamani

et al. 2021

OPTH

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“…A recent paper describes the current state of ROP in eight LMICs. 23 The incidence of ROP was not available for all countries. This incidence, mostly based on smaller studies in one institution, ranged from 14% to 50%.…”

Section: Discussionmentioning

confidence: 99%

Multicentre survey of retinopathy of prematurity in Indonesia

Siswanto

Bos

Dijk

et al. 2021

bmjpo

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BackgroundThe incidence of retinopathy of prematurity (ROP) is higher in Indonesia than in high-income countries. In order to reduce the incidence of the disease, a protocol on preventing, screening and treating ROP was published in Indonesia in 2010. To assist the practical implementation of the protocol, meetings were held in all Indonesia regions, calling attention to the high incidence of ROP and the methods to reduce it. In addition, national health insurance was introduced in 2014, making ROP screening and treatment accessible to more infants.ObjectiveTo evaluate whether the introduction of both the guideline drawing attention to the high incidence of ROP and national health insurance may have influenced the incidence of the disease in Indonesia.SettingData were collected from 34 hospitals with different levels of care: national referral centres, university-based hospitals, and public and private hospitals.MethodsA survey was administered with questions on admission numbers, mortality rates, ROP incidence, and its stages for 2016–2017 in relation to gestational age and birth weight.ResultsWe identified 12 115 eligible infants with a gestational age of less than 34 weeks. Mortality was 24% and any stage ROP 6.7%. The mortality in infants aged less than 28 weeks was 67%, the incidence of all-stage ROP 18% and severe ROP 4%. In the group aged 28–32 weeks, the mortality was 24%, all-stage ROP 7% and severe ROP 4%–5%. Both mortality and the incidence of ROP were highest in university-based hospitals.ConclusionsIn the 2016–2017 period, the infant mortality rate before 32 weeks of age was higher in Indonesia than in high-income countries, but the incidence of ROP was comparable. This incidence is likely an underestimation due to the high mortality rate. The ROP incidence in 2016–2017 is lower than in surveys conducted before 2015. This decline is likely due to a higher practitioner awareness about ROP and national health insurance implementation in Indonesia.

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“… 4 Thus, middle-income countries are currently suffering from an ROP epidemic while incidence is also increasing slowly in low-income nations. 5 Bowe et al found that ROP screening criteria may need to be adjusted according to the country’s NICU capabilities and unique challenges. 5 …”

Section: Introductionmentioning

confidence: 99%

Pitfalls of Advanced Retinopathy of Prematurity Presentation: A Content Analysis of Medical Records

AlBat’hi¹,

Abouammoh²,

Alswaina³

et al. 2021

RMHP

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Purpose: To identify the pitfalls in retinopathy of prematurity (ROP) screening leading to advanced disease at Ministry of Health (MOH) hospitals in Saudi Arabia. Methods: A qualitative deductive content analysis was used to study the phenomena of defects in ROP screening. A retrospective review of medical records of newborns presenting to two tertiary eye care centers with advanced ROP (stage 4 and 5) from January 2012 to June 2019 was completed. An extensive review of the original files at the referring hospitals was conducted, including the general condition and findings of ophthalmic examination and the sequence of follow-up until the infant was discharged/referred. Data analysis was completed using pre-structured categorization matrix. Results: Records of 29 infants with advanced stage ROP were identified. Only 13 medical records were available and obtained. The pitfalls in screening found in the study were failure to refer by the neonatologist, delayed follow-up by the ophthalmologist, failure to follow-up by the ophthalmologist, failure to diagnose by the ophthalmologist, poor documentation in patient files, unavailability of ophthalmologist, family negligence, lack of treatment and delayed referral to a higher center, and progression despite timely screening and management. Conclusion:Although clear ROP screening guidelines are available, implementations of these guidelines are suboptimal. This study showed that the most common defect in screening is physician's inadequacy and unavailability. A proper network of competent ROP screening physicians in all neonatal intensive care units should be established. Centers for advanced ROP surgery should be allocated to deliver a timely surgical care if needed.

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The current state of retinopathy of prematurity in India, Kenya, Mexico, Nigeria, Philippines, Romania, Thailand, and Venezuela

Cited by 54 publications

References 30 publications

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Multicentre survey of retinopathy of prematurity in Indonesia

Pitfalls of Advanced Retinopathy of Prematurity Presentation: A Content Analysis of Medical Records

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