SSRIs in a case of selective mutismSara, an 8-year-old girl of Asian descent, was referred for psychiatric assessment in grade 3. She was the elder of 2 children in a stable, intact, middleclass family. Sara was temperamentally shy and spoke English with a slight accent, but her development history was otherwise unremarkable. Sara's parents immigrated to Canada shortly before her birth, but they spoke English with their children at home and reported Sara's speech to be normal there. Starting in kindergarten, Sara did not speak to teachers, but she whispered to her sister and 1 familiar peer in the school yard. Many behavioural strategies were attempted to elicit speech in class, but none succeeded. In grade 1, Sara's pediatrician recommended fluoxetine, but her parents were unwilling to consider psycho tropic medication for her at that time. In the ensuing 2 years, Sara's functioning deteriorated. According to Sara's grade 2 progress report card, her teacher was "unable to evaluate" Sara for many subjects and subsequently raised the possibility of her having a developmental delay. Sara's familiar peer moved away, increasing her social isolation.After a thorough assessment, consultation with Sara's school and several family discussions about the risks and benefits of medication, Sara's parents reluctantly agreed to a trial of fluoxetine. Sara experienced no adverse effects from this medication. After 3 weeks of taking 10 mg of fluoxetine per day, Sara appeared more relaxed and began talking to her sister's friends. Concurrently, her grade 3 teacher patiently spent a few minutes each day reading and talking to Sara one-on-one.After about 8 weeks on medication, Sara began answering her teacher's questions, and soon afterwards she began speaking in class. Relieved, her parents decided to discontinue medication, and proudly announced "All she needed was the right teacher." They declined further psychi atric follow-up.Sara's case represents a typical example of selective mutism, a condition where children fail to speak in certain social situations despite generally being able to speak at home. Minor abnormalities of speech or speaking English as a second language are common in these children and may contribute to their self-consciousness or social anxiety. Given the frequent link between selective mutism and social anxiety, selective serotonin reuptake inhibitors (SSRIs) are sometimes considered, especially in patients in whom psychosocial intervention has failed. As in Sara's case, parents are usually reluctant to medicate young children, which often results in treatment delays and deterioration in functioning. Further increasing parents' and clinicians' concerns about medical treatment, pharmacotherapy for selective mutism is off-label, evidence for SSRIs is limited and the long-term effects of SSRIs in this population are unknown. Evidence supporting the use of SSRIs to treat patients with selective mutism consists mostly of case reports and open trials, and includes fewer than 100 cases in total.2,3 A positive ran...