The Current Landscape of Pharmacotherapies for Sarcopenia

Bahat, Gulistan; Ozkok, Serdar

doi:10.1007/s40266-023-01093-7

Cited by 5 publications

(2 citation statements)

References 276 publications

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“…As people age, the circulation levels of many anabolic hormones decrease, which may lead to muscle mass and function changes. As a result, hormone modulation has been examined as the foundation of emerging sarcopenia therapeutic strategies, with testosterone supplementation being the most commonly involved drug for enhancing muscle mass and increasing muscle-protein anabolism [12,53,57]. However, the findings of testosterone replacement therapy studies in males vary depending on the participant's age, pre-treatment testosterone levels, and administration methods.…”

Section: New Therapeutic Formulationsmentioning

confidence: 99%

“…Considering the close relationship between skeletal muscle function, glucose, and fat metabolism in both healthy individuals and those with comorbidities, several other drugs, such as BIO101, GLP-1 receptor agonists, DPP4 inhibitors, and SGLT2 inhibitors, stand out as promising options to be evaluated in sarcopenia clinical studies [23,57,62].…”

Section: New Therapeutic Formulationsmentioning

confidence: 99%

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Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

Najm,

Niculescu,

Grumezescu

et al. 2024

IJMS

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Sarcopenia is a prevalent degenerative skeletal muscle condition in the elderly population, posing a tremendous burden on diseased individuals and healthcare systems worldwide. Conventionally, sarcopenia is currently managed through nutritional interventions, physical therapy, and lifestyle modification, with no pharmaceutical agents being approved for specific use in this disease. As the pathogenesis of sarcopenia is still poorly understood and there is no treatment recognized as universally effective, recent research efforts have been directed at better comprehending this illness and diversifying treatment strategies. In this respect, this paper overviews the new advances in sarcopenia treatment in correlation with its underlying mechanisms. Specifically, this review creates an updated framework for sarcopenia, describing its etiology, pathogenesis, risk factors, and conventional treatments, further discussing emerging therapeutic approaches like new drug formulations, drug delivery systems, stem cell therapies, and tissue-engineered scaffolds in more detail.

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Section: New Therapeutic Formulationsmentioning

confidence: 99%

Section: New Therapeutic Formulationsmentioning

confidence: 99%