The current and advanced therapeutic modalities for wound healing management

Fallah, Nadia; Rasouli, Milad; Amini, Mohammad Reza

doi:10.1007/s40200-021-00868-2

Cited by 12 publications

(10 citation statements)

References 127 publications

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“…60 Sensory neuropathy causes disruption in the skin integrity and provides a route for microbial invasion, resulting in unhealed wounds, which later form chronic ulcers. 61 Autonomic neuropathy results in dysfunction of the sebaceous glands and sweat glands in the foot, leading to Nanoscale Advances Review a predisposition to ssures. Finally, the moisturizing capability of the foot is lost to a great extent and the overlying skin becomes vulnerable to infections and breaks.…”

Section: Diabetic Neuropathy (Dn)mentioning

confidence: 99%

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

et al. 2022

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Section: Diabetic Neuropathy (Dn)mentioning

confidence: 99%

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

et al. 2022

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“…Debridement, antiseptics, wound dressings, and negative pressure therapy are common ways of treating wounds. Newly developed nanomaterials have provided novel methods for wound treatment 5–7 . However, painful treatment, repeated medical visits, and the great expenses involved in treatment lead to poor patient compliance.…”

Section: Introductionmentioning

confidence: 99%

“…Newly developed nanomaterials have provided novel methods for wound treatment. [5][6][7] However, painful treatment, repeated medical visits, and the great expenses involved in treatment lead to poor patient compliance. In addition, the emergence of antibiotic resistance further increases delays in the healing process.…”

mentioning

confidence: 99%

“…the following limitations:(1) the CAP device used in this study only confirmed its efficacy and safety in trauma treatment through in vitro bactericidal effects and studies in rat scald models, and lacks more indepth mechanistic studies; (2) only male rats were observed for the study in the animal experiments, and whether there are gender differences in the effect of CAP on wound healing needs to be further explored;(3) no further studies on microbial infection of trauma and posttreatment conditions were conducted in the clinical study; (4) in the clinical study, patients had received various other treatments before CAP treatment, which may affect the final result;(5) the clinical sample of this study was very limited. To further confirm the efficacy and safety of CAP treatment, additional clinical samples should be included, randomized controlled observational studies should be conducted, and the treatment parameters should be explored.…”

mentioning

confidence: 99%

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Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Gao

Wang

et al. 2023

Bioengineering & Transla Med

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Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment.

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“…Cold plasma (CP) is well-known for its adjustable level of reactive oxygen and nitrogen species, UV radiation, and reliance on electromagnetic (EM) fields 37 . Food preservation 38 along with diverse applications such as plasma medicine 39 , 40 , CO 2 conversion 41 , water treatment 42 , 43 , textile 44 , etc. are some application areas of cold plasmas distinguishing the plasma technology from other technologies.…”

Section: Introductionmentioning

confidence: 99%

Synergistic cellulose-based nanocomposite packaging and cold plasma decontamination for extended saffron preservation

Amini

Rasouli

Ghoranneviss

et al. 2022

Sci Rep

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Sterilization of saffron packaging and maintaining the quality of saffron content are the main priorities in saffron preservation. Common modalities do not offer lasting saffron preservation and it is urgent to develop novel packaging approaches from renewable resources and prevent packaging waste. Here, simultaneous decontamination and quality maintenance of saffron is demonstrated, for the first time, through the synergistic application of nano-clay-loaded carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) nanocomposites (CNCs) and cold plasmas (CP). Compared to the separate uses of CP and CMC/PVA/nano clay, our results confirm the synergies between CP and CMC/PVA/nano clay cause complete inactivation of Escherichia coli bacteria, while not significantly affecting the concentrations of the essential saffron components (safranal, crocin, and picrocrocin). Overall, the CP-treated CMC/PVA/nano clay fosters saffron preservation, through contamination removal and quality maintenance of the food product. The synergistic application of CP and CMC/PVA/nano clay thus represents a promising strategy for packaging, sterilization, and preservation of high-value food products.

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The current and advanced therapeutic modalities for wound healing management

Cited by 12 publications

References 127 publications

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Synergistic cellulose-based nanocomposite packaging and cold plasma decontamination for extended saffron preservation

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