The curious history behind a biologic-enriched cat food: Hyperimmune avian IgY as a means of oral adoptive passive immunization

Steinberg, Joshua

doi:10.1016/j.jaci.2021.06.031

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Das zweite Konzept wurde von der Firma Nestlé Purina entwickelt, die Tierfutter herstellt. Hierbei werden die besonderen Eigenschaften von IgY genutzt, einem Immunglobulin, welches Teil der immunologischen Antwort von Vögeln ist 20 . IgY kann von Säugetieren oral aufgenommen werden, übersteht ohne Zerstörung die Magenpassage und wird intakt im Darm resorbiert.…”

Section: Alternative Therapieoptionenunclassified

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Tierallergie

Lange

2024

Kinder- und Jugendmedizin

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ZUSAMMENFASSUNGTierallergien sind ein häufiges und relevantes Thema in der allergologischen Praxis. 69 % der deutschen Haushalte mit Kindern besitzen ein Haustier. Fast 13 % aller Kinder sind gegen Haustiere sensibilisiert. Viele dieser Sensibilisierungen sind jedoch klinisch nicht relevant. Durch eine gute Anamnese und mithilfe moderner diagnostischer Methoden ist es möglich, das auslösende Tier genauer zu identifizieren und die Relevanz zu klären. Klare und differenzierte Meidungsempfehlungen können die Allergenlast in der Umgebung der Patienten senken.Leider sind viele Fragen zur Tierallergie offen und etablierte Therapieempfehlungen fehlen. In diesem Artikel werden verschiedene Optionen zur Diagnostik und Therapie vorgestellt.

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Section: Alternative Therapieoptionenunclassified

“…In kleineren Studien zeigte sich eine um 50 % reduzierte Allergenkonzentration in der Umgebung behandelter Katzen. Katzenallergische Patienten zeigten zwar eine Besserung der Beschwerden, diese erreichte jedoch kein Signifikanzniveau 20 , 21 . Trotzdem ist das IgY-angereicherte Katzenfutter derzeit in Deutschland erhältlich.…”

Section: Alternative Therapieoptionenunclassified

Tierallergie

Lange

2024

Kinder- und Jugendmedizin

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“…Also, another interesting allergen‐specific approach was launched: Cat food containing chicken IgY against Fel d 1 expressed in yolks of eggs from chickens kept with cats 22,23 . The resistant IgY antibody is enterally absorbed and secreted into saliva where it complexes Fel d 1 23–25 . Its efficacy to reduce Fel d 1 in saliva and then also on cat dander was recently shown in 114 cat allergic patients 26 .…”

Section: Introductionmentioning

confidence: 99%

“… 22 , 23 The resistant IgY antibody is enterally absorbed and secreted into saliva where it complexes Fel d 1. 23 , 24 , 25 Its efficacy to reduce Fel d 1 in saliva and then also on cat dander was recently shown in 114 cat allergic patients. 26 Clearly, in this case, the food is harmless and non‐invasive for the cats and also here no side effects for the animals were so far documented.…”

Section: Introductionmentioning

confidence: 99%

The holo beta‐lactoglobulin lozenge reduces symptoms in cat allergy—Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge

Bergmann

Raab²,

Graessel

et al. 2023

Clinical & Translational All

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Background The allergists´ tool box in cat allergy management is limited. Clinical studies have shown that holo beta‐lactoglobulin (holoBLG) can restore micronutritional deficits in atopic immune cells and alleviate allergic symptoms in a completely allergen‐nonspecific manner. With this study, we aimed to provide proof of principle in cat allergy. Methods A novel challenge protocol for cat allergy in a standardized ECARF allergen exposure chamber (AEC) was developed. In an open pilot study (NCT05455749), patients with clinically relevant cat allergy were provoked with cat allergen for 120 min in the AEC before and after a 3‐month intervention phase (holoBLG lozenge 2x daily). Nasal, conjunctival, bronchial, and pruritus symptoms were scored every 10 min– constituting the total symptom score (TSS). Peak nasal inspiratory flow (PNIF) was measured every 30 min. In addition, a titrated nasal provocation test (NPT) was performed before and after the intervention. Primary endpoint was change in TSS at the end of final exposure compared to baseline. Secondary endpoints included changes in PNIF, NPT, and occurrence of late reactions up to 24 h after exposure. Results 35 patients (mean age: 40 years) completed the study. Compared to baseline, holoBLG supplementation resulted in significant improvement in median TSS of 50% (p < 0.001), as well as in median nasal flow by 20 L/min (p = 0.0035). 20% of patients reported late reactions after baseline exposure, but 0% after the final exposure. Conclusions Cat allergic patients profited from targeted micronutrition with the holoBLG lozenge. As previously seen in other allergies, holoBLG supplementation also induced immune resilience in cat allergies, resulting in significant symptom amelioration.

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Study on functional improvement of freeze–thaw egg yolk pellet by enzymatic hydrolysis

Gao

Chang

et al. 2022

J Food Sci Technol

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The curious history behind a biologic-enriched cat food: Hyperimmune avian IgY as a means of oral adoptive passive immunization

Cited by 3 publications

References 10 publications

Tierallergie

Tierallergie

The holo beta‐lactoglobulin lozenge reduces symptoms in cat allergy—Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge

Study on functional improvement of freeze–thaw egg yolk pellet by enzymatic hydrolysis

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