The Curative Effect of Berberine Nanoparticles and Cisplatin Combination Therapies Against Hepatocarcinogenesis-Induced By N-Nitroso-Diethylamine In Male Rat
Abstract:This study aimed to investigate whether berberine nanoparticles (BBR-NPs) and/or cisplatin supplementation could prevent hepatocarcinogenesis-induced by N-nitroso-diethylamine (DENA) in male rats. Male Wistar albino rats were divided into five groups; Group 1: Control; Group 2: DENA-CCl4; Group 3: DENA-CCl4+Cisplatin; Group 4: DENA-CCl4+BBR-NPs; Group 5: DENA-CCl4+Cisplatin+BBR-NPs. DENA-CCl4 significantly increase AST, ALT, ALP, LDH, GGT, AFP activities and total bilirubin, while, 5, NT, total protein and al… Show more
“…Berberine protected liver injury evidenced by decreased ALT and AST activities and shows hepatoprotective activity. Berberine reduces the ALP levels by acting on the bile duct (Mohamed NA et al, 2018) 23 . In 2018 Zheng Z et al, reported the hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice 24 .…”
Section: Fig 3: Effect Of Berberine On Serum Lipase Levels Of Dbtc Imentioning
“…Berberine protected liver injury evidenced by decreased ALT and AST activities and shows hepatoprotective activity. Berberine reduces the ALP levels by acting on the bile duct (Mohamed NA et al, 2018) 23 . In 2018 Zheng Z et al, reported the hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice 24 .…”
Section: Fig 3: Effect Of Berberine On Serum Lipase Levels Of Dbtc Imentioning
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