The curative effect of Bee Venom and Propolis on oxidative stress induced by γ-irradiation on blood and tissues of rats

Elshater, Abd-Elraheim A.; Mohi-Eldin, Mouchira M.; Salman, Muhammad; Kasem, Naglaa R. A.

doi:10.21608/eajbsc.2014.16047

Cited by 8 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the reduction of lipid peroxidation-mediated oxidative stress may be an effective strategy for the prevention and treatment of hepatorenal injuries. Inconsistent with the report of both Abdel-rahman and AbdelMoneim [42], and Elshater et al [43], the present study showed that treatment of GM pretreated rats with NnvE significantly decreased MDA levels which may be due to its antioxidant mechanism. Several reports stated that bee venom therapy is a potent antioxidant that led to a decrease in the levels of reactive oxygen species (ROS) [44,45].…”

Section: Discussionsupporting

confidence: 82%

Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Mohamed¹,

Sayed²,

Moftha³

et al. 2021

GSC Adv. Res. Rev.

View full text Add to dashboard Cite

Background: In developing countries, there is no doubt that acute kidney injury and chronic liver diseases have a major impact on health. Different venom components are gaining renewed interest as potential sources of new pharmacological compounds relevant for human therapeutics. Aim: The present study was designed to evaluate the therapeutic efficacy of the crude venom extract of the Egyptian spitting cobra (Naja nubiae) venom extract against gentamycin–induced nephrotoxicity and hepatotoxicity in rats. Methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and venom extract. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, intraperitoneal) for 8 days. Results: LD50 of venom extract in rats was 0.2mg/kg. The venom extract group showed a significant decrease in the liver enzymes, urea, uric acid, creatinine, malondialdehyde meanwhile glutathione reduced and catalase levels increased. Histological examination of liver and kidney mild protective efficacy with less extensive degenerative changes in the tissues of venom extract grou Conclusion: The results of the present investigation showed that administration of venom extract proved therapeutic efficacy against gentamycin -induced hepatorenal dysfunction by maintain the normal functional status of the liver and kidney and normalized the antioxidant system.

show abstract

Section: Discussionsupporting

confidence: 82%

Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Mohamed¹,

Sayed²,

Moftha³

et al. 2021

GSC Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…Bee venom and its bradykinin-potentiating factor protection against hepatoand nephrotoxicity were reported (Bekheeta, Awadallaa, Salmanb, & Hassan, 2013;Darwish et al, 2013). Moreover, bee venom has a protective effect against impairment in liver and kidney tissues that is induced by gamma radiation where bee venom had significantly decreased the elevation of serum ALT, AST, and ALP (Elshater et al, 2014). The hepatoprotective effect of bee venom was attributed to inhibiting the secretion of pro-inflammatory cytokines and decreasing the elevated serum aminotransferase enzymes in different models of induced hepatic injury and nephrotoxicity (Hegazi, 2012;Hyunseong et al, 2013;Park et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…It has been used to treat a variety of diseases and complications such as arthritis, rheumatism, back pain, cancerous tumors, and skin disease (Tu, Wu, Hsieh, Chen, & Hsu, 2008;Jang et al, 2009;Lee et al, 2009). Also, bee venom has a curative effect on oxidative stress induced by γ-irradiation (Elshater, Mohi Eldin, Salman, & Kasem, 2014) and protective effect against acute pancreatitis (Seo et al, 2008). In addition, several biological properties were reported such as neuroprotection (Khalil, Assaf, ElShebiney, & Salem, 2015;Yoon & Lee, 2013), beneficial effects in the treatment of Parkinson disease (Alvarez- Fischer et al, 2013), decrease in the complications of diabetes and multiple sclerosis (Chen & Lariviere, 2010;Javad, Adeleh, & Ali, 2014;Orśolić, 2012;Son et al, 2007), hepatoprotective characteristics (Darwish, El-Bakly, Arafa, & El-Demerdash, 2013), and anticancer and radioprotective characteristics (Gajski & Garaj-Vrhovac, 2009;Orśolić, 2012).…”

Section: Introductionmentioning

confidence: 99%

Counter effect of bee venom and its extracted bradykinin-potentiating factor on acrylamide and chips administration-induced complications in the liver and kidney of male mice

Amra

Lashein

Seleem

et al. 2018

JoBAZ

View full text Add to dashboard Cite

Background: Acrylamide has been reported to induce hepato-and nephrotoxicity. The present investigation aims to alleviate the dangerous effects at the histopathological and physiological levels of acrylamide by bee venom and its extracted bradykinin-potentiating factor (BPF). Seventy-five adult male mice were divided into 15 groups: a control (G1) 15 animals for 30 (G1.1), 45 (G 1.2), and 60 (G 1.3) days of experimental periods; acrylamide-administered G2.1, G2. 2, and G2.3 received acrylamide orally (10 mg/kg b.w) daily for 30, 45, and 60 days. Chips-administered G3.1, G3.2, and G3.3 were fed one third of its daily diet by chips for 30, 45, and 60 days. Bee venom-and BPF-treated G4.1 and G4.2 were i.p. injected with bee venom (1.319 mg/kg b.w.) and BPF (2.314 mg/kg b.w.), respectively, day after the other day for 60 days. G5.1 and G5.2 received acrylamide orally (10 mg/kg b.w) combined either with i.p. by bee venom (1.319 mg/kg b.w.) or BPF (2.314 mg/kg b.w.) respectively day after the other day for 60 days. G6.1 and G6.2 were fed one third of its daily diet by chips for 60 days combined either with i.p. by bee venom (1.319 mg/kg b.w.) or with BPF (2.314 mg/kg b.w.), respectively, day after the other day for 60 days. Results: The results showed that acrylamide administration and chips feeding groups suffer from alteration and histopathological changes in liver and kidney tissues that were accompanied with the increase in liver and kidney physiological biomarker (ALT, AST, urea, creatinine, uric acid) and the decrease in the albumin levels. Acrylamide or chips combined with either bee venom or BPF showed improvement in the level of physiological and histopathological studies. Conclusion:The study concluded the protective role of bee venom and its extracted BPF against acrylamide-and chips-induced hepato-and nephrotoxicity.

show abstract

“…These parameters included body mass, lean body mass, fat tissue mass, serum lipids, blood sugar, uric acid, arterial pressure, and pulse rate before and after functional loading tests 32 . Furthermore, a combination of propolis and bee venom showed a marked curative effect on OS produced by gamma radiation in rats 33 . Additionally, a combination treatment consisting of aqueous extract of propolis and bee venom induced synergistic antiproliferative effects in breast cancer cells 34 .…”

Section: Introductionmentioning

confidence: 94%

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

El-Hakam

Laban

El-Din

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Hypertension-induced ventricular and vascular remodeling causes myocardial infarction, heart failure, and sudden death. Most available pharmaceutical products used to treat hypertension lead to adverse effects on human health. Limited data is available on apitherapy (bee products) combinations for treatment of hypertension. This study aims to evaluate the antihypertensive effects of combinations of natural apitherapy compounds used in the medical sector to treat a variety of diseases. Rats were assigned into six groups consisting of one control group and five hypertensive groups where hypertension (blood pressure > 140/90) was induced with dexamethasone. One of these groups was used as a hypertension model, while the remaining four hypertensive groups were treated with a propolis, royal jelly, and bee venom combination (PRV) at daily oral doses of 0.5, 1.0, and 2.0 mg/kg, and with losartan 10 mg/kg. The PRV combination at all doses decreased arterial blood pressure below the suboptimal value (p < 0.001), and PRV combination treatment improved dexamethasone-induced-ECG changes. The same treatment decreased angiotensin-II, endothelin-1, and tumor growth factor β serum levels in hypertensive rats. Additionally, PRV combination improved histopathological structure, and decreased serum levels of NF-kB and oxidative stress biomarkers. We concluded that PRV combination therapy may be used as a potential treatment for a variety of cardiovascular diseases.

show abstract

The curative effect of Bee Venom and Propolis on oxidative stress induced by γ-irradiation on blood and tissues of rats

Abstract: and is devoted to publication of original papers that elucidate important biological, chemical, or physical mechanisms logical significance. of broad physio www.eajbs.eg.net Provided for non-commercial research and education use. Not for reproduction, distribution or commercial use.

Cited by 8 publications

References 42 publications

Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Counter effect of bee venom and its extracted bradykinin-potentiating factor on acrylamide and chips administration-induced complications in the liver and kidney of male mice

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

Contact Info

Product

Resources

About