The Curative Action of Sulpharsphenamine in Experimental Syphilis

Voegtlin, Carl; Armstrong, Caren; Dyer, Helen A.

doi:10.2307/4576832

Public Health Reports (1896-1970)

1923

DOI: 10.2307/4576832

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The Curative Action of Sulpharsphenamine in Experimental Syphilis

Carl Voegtlin¹,

Caren Armstrong²,

Helen A. Dyer³

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1927

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“…These experiments offer convincing proof of the efficacy of these two drugs in eliminating virulent treponemata from the lymphoid tissues of the experimentally infected animal. Voegtlin, Armstrong, and Dyer (10) were able to abolish lymph node infection in the rabbit by single doses of sulfarsphenamine and neoarsphenamine.…”

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Experimental Observations on the "Cure" of Syphilis in the Rabbit With Arsphenamine

Chesney

Kemp

1924

Journal of Experimental Medicine

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The first therapeutic studies of arsphenamine were carried out by Ehrlich and Hata (1) on mice and rats infected with the organism of relapsing fever, on fowls with fowl spirillosis, and on rabbits with experimental syphilis. Rabbits with scrotal chancres were treated with the drug and the rate of healing of the lesion and of the disappearance of treponemata was noted. Rapid disappearance of the clinical phenomena and of the treponemata was interpreted by Ehrlich and Hata to mean that the animals had been sterilized, in other words, that complete biological cure had been obtained. The more recent knowledge of the behavior of syphilis in the rabbit permits us to say that these criteria of cure are altogether insufficient.Kuznitsky (2), working under Neisser's direction, studied the effects of arsphenamine upon syphilis in apes and obtained what he regarded as certain cure in six out of nine animals treated. The criterion for cure adopted by this worker was the success or failure of reinoculation. If reinoculation proved to be successful the animal was regarded as having been rid of all its spirochetes; if unsuccessful, it was thought that infection still existed. In therapeutic experiments with other arsenicals and with various mercurials Neisser (3) had used either the reinoculation method as a criterion of cure, or had inoculated emulsions of internal organs (liver, spleen, bone marrow) of treated animals into normal apes to determine whether

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Experimental Observations on the "Cure" of Syphilis in the Rabbit With Arsphenamine

Chesney

Kemp

1924

Journal of Experimental Medicine

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Mercurosal in Experimental Rabbit Syphilis

Gruhzit¹

1925

Arch Dermatol

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The Curability of Syphilis

Chesney¹,

Kemp²

1927

JAMA

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The Curative Action of Sulpharsphenamine in Experimental Syphilis

Cited by 3 publications

References 0 publications

Experimental Observations on the "Cure" of Syphilis in the Rabbit With Arsphenamine

Experimental Observations on the "Cure" of Syphilis in the Rabbit With Arsphenamine

Mercurosal in Experimental Rabbit Syphilis

The Curability of Syphilis

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