The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli

Hill-Bowen, Lauren D.; Riedel, Michael C.; Poudel, Ranjita; Salo, Taylor; Flannery, Jessica S.; Camilleri, Julia A.; Eickhoff, Simon B.; Laird, Angela R.

doi:10.1016/j.neubiorev.2021.08.010

Cited by 37 publications

(29 citation statements)

References 130 publications

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“…The OFC receives information from brain regions involved in sensory processing (e.g., insula, fusiform gyrus), affective processing (e.g., amygdala), and memory (e.g., hippocampus), and plays a prominent role in integrating, encoding, and retrieving reward value about stimulus [ 103 ]. There is a strong and consistent activation of the OFC in reward-related tasks such as decision-making tasks [ 104 ] or cue-reactivity tasks [ 105 ]. Further, several studies have shown that the magnitude of activity in this region correlated with pleasantness or tastiness ratings of food/food cues [ 106 , 107 , 108 ].…”

Section: Discussionmentioning

confidence: 99%

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Yang

Morys

2021

Brain Sciences

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Overconsumption of high-calorie or unhealthy foods commonly leads to weight gain. Understanding people’s neural responses to high-calorie food cues might help to develop better interventions for preventing or reducing overeating and weight gain. In this review, we conducted a coordinate-based meta-analysis of functional magnetic resonance imaging studies of viewing high-calorie food cues in both normal-weight people and people with obesity. Electronic databases were searched for relevant articles, retrieving 59 eligible studies containing 2410 unique participants. The results of an activation likelihood estimation indicate large clusters in a range of structures, including the orbitofrontal cortex (OFC), amygdala, insula/frontal operculum, culmen, as well as the middle occipital gyrus, lingual gyrus, and fusiform gyrus. Conjunction analysis suggested that both normal-weight people and people with obesity activated OFC, supporting that the two groups share common neural substrates of reward processing when viewing high-calorie food cues. The contrast analyses did not show significant activations when comparing obesity with normal-weight. Together, these results provide new important evidence for the neural mechanism underlying high-calorie food cues processing, and new insights into common and distinct brain activations of viewing high-calorie food cues between people with obesity and normal-weight people.

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Section: Discussionmentioning

confidence: 99%

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Yang

Morys

2021

Brain Sciences

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“…A principal feature of drug addiction is overconsumption followed by a reduced ability to control the desire to obtain drugs regardless of the risks involved, ultimately resulting in compulsive drug seeking [ 7 ]. The possibility that environmental stimuli associated with the postingestive rewarding effects of drugs strongly motivate consumption has guided much of the research exploring the role of neuroadaptations in the mesolimbic and mesocortical dopamine systems as well as in the prefrontal and orbitofrontal cortices mediating responses to drug rewards [ 5 , 274 ]. There is little doubt that the memory of highly rewarding postingestive drug effects can strongly influence expectations about the outcomes a particular drug will produce.…”

Section: Drug Regulationmentioning

confidence: 99%

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Riley

Manke

Huang

2022

Behavioural Neurology

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Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug-taking patterns transition from impulsive (acute use) to compulsive (chronic use) as a function of various neuroadaptations leading to the downregulation of DA systems, upregulation of stress systems, and the dysregulation of the prefrontal/orbitofrontal cortex. Although the nature of reinforcement in the initiation and mediation of these effects may differ (positive vs. negative), the role of reinforcement in drug intake (acute and chronic) is well characterized. However, drugs of abuse have other stimulus properties that may be important in their use and abuse. One such property is their aversive effects that limit drug intake instead of initiating and maintaining it. Evidence of such effects comes from both clinical and preclinical populations. In support of this position, the present review describes the aversive effects of drugs (assessed primarily in conditioned taste aversion learning), the fact that they occur concurrently with reward as assessed in combined taste aversion/place preference designs, the role of aversive effects in drug-taking (in balance with their rewarding effects), the dissociation of these affective properties in that they can be affected in different ways by the same manipulations, and the impact of various parametric, experiential, and subject factors on the aversive effects of drugs and the consequent impact of these factors on their use and abuse potential.

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“…In addition, hyperactivity of reward network and salience network were found when drug-dependent patients were confronted with drug-related cues ( 12 , 15 , 16 ). Somewhat counterintuitively, hyperactivity of executive network and attention network was also reported in drug-dependent patients when exposed to the drug-related cues ( 11 , 12 , 17 ). Since these networks both play a primary role in inhibitory control and self-regulation, the hyper-engagement of the executive and attention network suggests the recruitment of cognitive resources when they were confronting with drug-related cues ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In recent years, neuroimaging techniques have been increasingly used to identify neural correlates of cue-induced craving ( 8 – 11 ). Functional magnetic resonance imaging (fMRI) studies have revealed several brain networks associated with the cue-induced craving ( 11 , 12 ). Inherent to the cue-reactivity paradigm, the visual processing network showed enhanced activation levels when exposed to drug-related cues ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Altered EEG Microstates Dynamics During Cue-Induced Methamphetamine Craving in Virtual Reality Environments

Lin

Cheng³

et al. 2022

Front. Psychiatry

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BackgroundCue-induced craving is widely considered to be the most important risk factor for relapse during abstinence from methamphetamine (Meth). There is limited research regarding electroencephalography (EEG) microstates of Meth-dependent patients under exposure to drug-related cues. Our objective was to investigate whether EEG microstate temporal characteristics could capture neural correlates of cue-induced Meth craving in virtual reality (VR) environments.MethodsEEG recordings of 35 Meth-dependent patients and 30 healthy controls (HCs) were collected during eyes-open state and cue-induced state, respectively. Group differences and condition differences in temporal parameters of four microstate classes were compared.ResultsThe results demonstrated the greater presence of microstate B in both Meth-dependent patients and HCs during the cue-induced condition, compared to resting state. In addition, for Meth-dependent patients, microstate C occurred significantly less frequently, along with a tendency of increased occurrence for class D during the cue-induced condition, compared to resting state. However, the change direction of class C and class D in HCs was completely opposite to that of Meth-dependent patients. The cue-induced condition also elicited different changes in transition probability between Meth-dependent patients and HCs.ConclusionThis study explored the features of EEG microstates in Meth-dependent patients during the cue-induced condition, which can improve our understanding of Meth addiction and contribute to the development of effective assessments and intervention tools.

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The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli

Cited by 37 publications

References 130 publications

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Altered EEG Microstates Dynamics During Cue-Induced Methamphetamine Craving in Virtual Reality Environments

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