The Cuban Twin Registry: Initial Findings and Perspectives

Marcheco-Teruel, Beatriz; Cobas-Ruiz, Marcia; Cabrera-Cruz, Niviola; Lantigua-Cruz, Araceli; García-Castillo, Elsa; Lardoeyt-Ferrer, Roberto; Robaina-Jiménez, Zoe; Fuentes-Smith, Evelyn; Morales-Calatayud, Francisco; Lemus-Valdés, María Teresa; Portuondo-Sao, Miriam; Comas-Pérez, Lenier; Pérez-Crispí, Juan M.; Villa, Thais Díaz-De Villal; Icart-Perera, Emelia; Jordán-Hernández, Aida; Lage‐Castellanos, Agustín; Rabell-Piera, Sergio; Rodriguez, Juan J. Llibre; Valdés‐Sosa, Pedro A.; Valdés-Sosa, Mitchell

doi:10.1017/thg.2012.135

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Few studies, however, have examined measured genes for alcohol dependence, or for that matter the heritability of alcoholism in Hispanic American samples (Harden et al , 2013, Konishi et al , 2003, Konishi et al , 2004, Norden-Krichmar et al , 2014). One family study of heart disease in Mexican Americans estimated the heritability of alcohol use disorders at 30% (Olvera et al , 2011), while a Cuban twin study estimated it to be 57% (Marcheco-Teruel et al , 2013). …”

Section: Introductionmentioning

confidence: 99%

Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics

2016

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Background Both a family history of alcoholism and migration-related factors like U.S. versus foreign nativity increase the risk for developing alcohol use disorders in Hispanic Americans. For this study, we integrated these two lines of research to test whether the relationship between familial alcoholism and alcohol dependence changes with successive generations in the U.S. Methods Data were from the wave 1 and wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Subjects self-identified Hispanic ethnicity (N = 4,122; n = 1,784 first, n = 1,169 second, and n = 1,169 third or later generation) and reported ever consuming 12 or more drinks in a one-year period. A family history of alcoholism was assessed in first and second degree relatives. Analyses predicting the number of alcohol dependence symptoms were path models. Results Alcohol dependence symptoms were associated with a stronger family history of alcoholism and later generational status. There was a significant interaction effect between familial alcoholism and generational status; the relationship of familial alcoholism with alcohol dependence symptoms increased significantly with successive generations in the U.S., more strongly in women than men. Acculturation partially mediated the interaction effect between familial alcoholism and generational status on alcohol dependence, although not in the expected direction. Conclusions Familial alcoholism interacted with generational status in predicting alcohol dependence symptoms in U.S. Hispanic drinkers. This relationship suggests that heritability for alcoholism is influenced by a higher order environmental factor, likely characterized by a relaxing of social restrictions on drinking.

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Section: Introductionmentioning

confidence: 99%

Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics

2016

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“…Besides, the Hungarian twin registry has changed its approach from voluntary registration to population‐based registration 25 . Thus, the majority of twin registries are known as population‐based registries, or they have taken a combination of voluntary and population‐based registration 39,41–44 …”

Section: Discussionmentioning

confidence: 99%

An information‐based framework for development national twin registry: Scoping review and focus group discussion

Abtahi

Gholamzadeh

Shahmoradi

et al. 2021

Health Planning & Management

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Background: Registries in various clinical domains have been established in the last decades. The specific genetic structure of twins has enabled researchers to find answers to the role of genetics and the environment in medical sciences. Thus, twin registries were developed across the world to support twin studies. Our main objective was to devise a conceptual model for developing the national twin registry to ensure the success of this registry. Methods:In this descriptive and qualitative study, the combination of literature review and focus group discussions was applied to achieve suitable models for developing a national twin registry based on lessons learned from founded registries. The qualitative synthesis and reporting results were conducted based on the COREQ checklist. Results: According to a systematic literature review, the characteristics and employed strategies employed by established twin registries were recognized. Moreover, based on our objectives, suitable models for registry development were defined. The source of information, the different levels of data, and the information flow were determined based on this model. Conclusion: Suggesting a conceptual framework for twin registry development at the national level based on the experiences of other countries could contribute to a greater understanding of twin registry implementation efficiently.

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“…The database contains extensive information from 55,400 twin pairs enrolled in the period 2004–2006 (Marcheco‐Teruel et al. ).…”

Section: Research In the Field Of Medical Geneticsmentioning

confidence: 99%

Genetics and genomic medicine in Cuba

Balbuena

Teruel

2017

Molec Gen & Gen Med

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The Cuban Twin Registry: Initial Findings and Perspectives

Cited by 8 publications

References 5 publications

Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics

Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics

An information‐based framework for development national twin registry: Scoping review and focus group discussion

Genetics and genomic medicine in Cuba

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