The Cu-containing TiO2 coatings with modulatory effects on macrophage polarization and bactericidal capacity prepared by micro-arc oxidation on titanium substrates

Huang, Qianli; Li, Xuezhong; Elkhooly, Tarek A.; Liu, Xujie; Zhang, Ranran; Wu, Hong; Feng, Qingling; Liu, Yong

doi:10.1016/j.colsurfb.2018.06.020

Cited by 70 publications

(65 citation statements)

References 33 publications

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“…Recent research has shown that biological elements, such as Cu, Ca, Zr, P and Si are beneficial for improving the bioactivity of materials, further enhancing implant osseointegration [32][33][34]. Huang et al [35] investigated bone regeneration and bactericidal capacity of MAO coatings on Ti in a Cu-containing electrolyte. Macrophage-mediated osteogenesis, macrophage polarization and macrophage bactericidal assay experiments showed that coating with higher content of Cu is more favourable for macrophage proliferation.…”

Section: Micro-arc Oxidationmentioning

confidence: 99%

“…The capture behavior of bacteria by macrophages is significant on the surface with high Cu content, which indicates that the bactericidal capacity of macrophages is promoted on the Cu-MAO surface. The white arrows indicate that bacteria are captured by macrophages [35]. Reprinted with permission from reference [35] 2018 Elsevier.…”

Section: Micro-arc Oxidationmentioning

confidence: 99%

“…The white arrows indicate that bacteria are captured by macrophages [35]. Reprinted with permission from reference [35] 2018 Elsevier. Researchers have investigated the effect of electrolyte composition on the microstructure and properties of titanium matrix micro-arc oxidation coating.…”

Section: Micro-arc Oxidationmentioning

confidence: 99%

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Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

2019

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With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is critical to the success of the implant. Thus, the implant surface is modified before implantation frequently, which can not only improve the mechanical properties of the implant, but also polish up bioactivity and osseoconductivity on a cellular level. This paper aims at reviewing titanium surface modification techniques for biomedical applications. Additionally, several other significant aspects are described in detail in this article, for example, micromorphology, microstructure evolution that determines mechanical properties, as well as a number of issues concerning about practical application of biomedical implants.

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Section: Micro-arc Oxidationmentioning

confidence: 99%

Section: Micro-arc Oxidationmentioning

confidence: 99%

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Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

2019

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“…Therefore, it is beneficial for bone tissue formation [12]. Moreover, copper exhibits excellent antibacterial properties versus a broad spectrum of bacteria, including gram-positive and gram-negative bacteria by interfering DNA replication and disrupting cell membranes [48][49][50].In particular, there have been some promising studies on the fabrication of antibacterial Cu/CuO-nanoparticles containing Cu-incorporated TiO 2 coatings on cp-Ti by using the MAO technique for the last five years [42,45,[51][52][53][54][55][56]. Wu et al investigated the formation and investigation of antibacterial resistances of Cu-incorporated TiO 2 coatings by MAO and hydrothermal treatment (HT) [42].…”

mentioning

confidence: 99%

“…In particular, there have been some promising studies on the fabrication of antibacterial Cu/CuO-nanoparticles containing Cu-incorporated TiO 2 coatings on cp-Ti by using the MAO technique for the last five years [42,45,[51][52][53][54][55][56]. Wu et al investigated the formation and investigation of antibacterial resistances of Cu-incorporated TiO 2 coatings by MAO and hydrothermal treatment (HT) [42].…”

mentioning

confidence: 99%

Characterization, Bioactivity and Antibacterial Properties of Copper-Based TiO2 Bioceramic Coatings Fabricated on Titanium

Durdu

2018

Coatings

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The bioactive and anti-bacterial Cu-based bioceramic TiO 2 coatings have been fabricated on cp-Ti (Grade 2) by two-steps. These two-steps combine micro-arc oxidation (MAO) and physical vapor deposition-thermal evaporation (PVD-TE) techniques for dental implant applications. As a first step, all surfaces of cp-Ti substrate were coated by MAO technique in an alkaline electrolyte, consisting of Na 3 PO 4 and KOH in de-ionized water. Then, as a second step, a copper (Cu) nano-layer with 5 nm thickness was deposited on the MAO by PVD-TE technique. Phase structure, morphology, elemental amounts, thickness, roughness and wettability of the MAO and Cu-based MAO coating surfaces were characterized by XRD (powder-and TF-XRD), SEM, EDS, eddy current device, surface profilometer and contact angle goniometer, respectively. The powder-and TF-XRD spectral analyses showed that Ti, TiO 2 , anatase-TiO 2 and rutile-TiO 2 existed on the MAO and Cu-based MAO coatings' surfaces. All coatings' surfaces were porous and rough, owing to the presence of micro sparks through MAO. Furthermore, the surface morphology of Cu-based MAO was not changed. Also, the Cu-based MAO coating has more hydrophilic properties than the MAO coating. In vitro bioactivity and in vitro antibacterial properties of the coatings have been investigated by immersion in simulated body fluid (SBF) at 36.5 • C for 28 days and bacterial adhesion for gram-positive (S. aureus) and gram-negative (E. coli) bacteria, respectively. The apatite layer was formed on the MAO and Cu-based MAO surfaces at post-immersion in SBF and therefore, the bioactivity of Cu-based MAO surface was increased to the MAO surface. Also, for S. aureus and E. coli, the antibacterial properties of Cu-based MAO coatings were significantly improved compared to one of the uncoated MAO surfaces. These results suggested that Cu-based MAO coatings on cp-Ti could be a promising candidate for biomedical dental implant applications.TiO 2 -based coatings have been suggested to improve corrosion resistance, bioactivity and biocompatibility of implant surfaces. They have recently received great attention for the biomedical applications owing to their more stable chemical composition [11,12]. TiO 2 were fabricated on cp-Ti by various surface coating methods including sol-gel [13], anodic oxidation [14], magnetron sputtering [15], electrophoretic deposition [16], acid etching [17,18], laser surface treatment [19], plasma spraying [20,21] and micro arc oxidation [22][23][24][25] etc. However, certain problems like non-homogenous structure, micro-structural control problems, micro-cracks formation, the presence of phase impurity, poor adhesion strength were observed in these methods except for MAO technique [26][27][28]. Thus, implant application areas of the coatings produced by these techniques are limited.Micro-arc oxidation (MAO) is one of the most applicable methods to deposit a porous and rough bioceramic layer on valve metals such as Ti, Al, Mg, and Zr surfaces [3,[29][30][31]. The MAO coating promotes bioacti...

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Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO 2 coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

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The Cu-containing TiO2 coatings with modulatory effects on macrophage polarization and bactericidal capacity prepared by micro-arc oxidation on titanium substrates

Cited by 70 publications

References 33 publications

Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

Characterization, Bioactivity and Antibacterial Properties of Copper-Based TiO2 Bioceramic Coatings Fabricated on Titanium

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

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