The crystal structure of L-dopa hydrochloride, 3-(3,4-dihydroxyphenyl)-L-alanine hydrochloride, C₉H₁₂O₄NCl

Crystal structure and Hirshfeld surface analysis of 1-carboxy-2-(3,4-dihydroxyphenyl)ethan-1-aminium bromide 2-ammonio-3-(3,4-dihydroxyphenyl)propanoate

“…4). Similar interactions are observed in dopa and its HCl form (Mostad et al, 1971;Jandacek & Earle, 1971;Mostad & Rømming, 1974).…”

“…In view of this interest, we have crystallized the title salt and report herein on its crystal structure. The hydrogen-bonding pattern and the relative contributions of various intermolecular interactions present are compared with the closely related chloride counterpart reported on earlier (Jandacek & Earle, 1971;Mostad & Rømming, 1974).…”

“…The crystal structures of l-dopa (Mostad et al, 1971) and its hydrochloride form (Jandacek & Earle, 1971;Mostad & Rømming, 1974) have been reported. Both of these compounds crystallized in the monoclinic space group P2 1 .…”

Crystal structure and Hirshfeld surface analysis of 1-carboxy-2-(3,4-dihydroxyphenyl)ethan-1-aminium chloride 2-ammonio-3-(3,4-dihydroxyphenyl)propanoate: a new polymorph of L-dopa HCl and isotypic with its bromide counterpart

“…Polymorphism is very common amongst pharamaceutically important molecules and is responsible for differences in many properties (Bernstein, 2002(Bernstein, , 2011Nangia, 2008;Guranda & Deeva, 2010). The first monoclinic form (I) [space group P2 1 and z 0 = 1] of l-dopa HCl was reported in the 1970s (Jandacek & Earle, 1971;Mostad & Rømming, 1974). Herein, we report on the crystal and molecular structure of a second monoclinic polymorph, form (II) (space group I2) of l-dopa HCl.…”

“…E72, [1544][1545][1546][1547][1548]. The title salt is a second monoclinic polymorph of the l-dopa HCl structure reported earlier in the monoclinic space group P2 1 [Jandacek & Earle (1971). Acta Cryst.…”