The crystal structure of gliotoxin

Fridrichsons, J.; Mathieson, A. McL

doi:10.1107/s0365110x67002944

Cited by 47 publications

(20 citation statements)

References 11 publications

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“…They agree within 16 ° with the correspond-'kh~/'~'Ll°4~ -~J 'l'f3'l "~'~ °~ ing values for sporidesmin G. c(,,,'~" '~;"o°~,', "<~ ~c,~, In dithio compounds such as sporidesmin and glio-(c) toxin (Fridrichsons & Mathieson, 1967) or 2lFthl < IAFI < 3IF, hi 1 667 unobserved reflexions, IFc maxl = 11.1. IFcl < l'0lFthl 596 l'0lftnl < IFcl < l-5lFthl 70…”

Section: Solution Of the Structure And Its Refinementsupporting

confidence: 69%

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The structure of sporidesmin G etherate

Przybylska¹,

Gopalakrishna²

1974

Acta Crystallogr Sect B

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Sporidesmin G etherate, C18H2006N384Cl.(C2Hs)20, a tetrathio compound, was obtained by treating sporidesmin (a disulphide) with dihydrogen disulphide. The crystals belong to the space group P21212, with unit-cell dimensions: a = 15" 160 (4), b = 21-369 (4) and c = 8.978 (4) A; Z= 4. The data were collected with a Picker automatic diffractometer. The structure was solved by the application of the tangent formula and refined by block-diagonal least-squares cycles to a final R value of 0.057. The tetrathiopiperazinedione moiety in sporidesmin G was found to be closely similar to the structure of an enantiomer described recently by Davis

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Section: Solution Of the Structure And Its Refinementsupporting

confidence: 69%

“…In sporidesmin they were 1.45 and 1.41 A and in sporidesmin G, 1"544 and 1.515 A respectively. The corresponding bond length in the pyrrolidine ring of gliotoxin (Fridrichsons & Mathieson, 1967) was found to be 1.52 A.…”

Section: Solution Of the Structure And Its Refinementmentioning

confidence: 99%

The structure of sporidesmin G etherate

Przybylska¹,

Gopalakrishna²

1974

Acta Crystallogr Sect B

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show abstract

“…The crystallographic work of Steitz et al 9 on the enzyme itself clearly shows that the ester group of the substrate must lie near the plane of the aromatic side chain in order to be attacked by OY-(Ser-195) so that D-I would bind productively in the equatorial mode. Blowto has suggested that the D / L specificity of I arises from more subtle differences in orientation of the ester group between D-I and L-I, emphasizing the exactness of fit which a good locked substrate must achieve.…”

Section: Appendixmentioning

confidence: 99%

Nature of the amino-enzyme intermediate in pepsin-catalyzed reactions

Silver¹,

Stoddard²,

Kelleher³

1976

J. Am. Chem. Soc.

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“…Low-melting nematic liquids having a negative dielectric anisotropy and thus capable of dynamic scattering were recently described''' also among esters of type (2) ["I. Nematic liquid crystals with positive dielectric anisotropy (E > E') cannot be excited to dynamic light scattering simply by electric fields, but they can find use as electrooptical detection or for electrically-controllable color filtersttt1 that can be used in polarized light.…”

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confidence: 99%

“…(2) The influence of the substituents R and R' on the mesomorphic properties is less marked with the diesters (3j than with the monoesters (2) in which the nature and chain length of the substituents is decisive for appearance or absence of nematic phases.…”

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confidence: 99%