The crystal structure of 2-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)thio)phenyl)isoindolin-1-one, C17H13F4NOS

Zhang, Jing; Zhang, Lixin

doi:10.1515/ncrs-2023-0042

Cited by 1 publication

(2 citation statements)

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“…The single-crystal structures of compounds 10d and 18 were determined (Figures S1 and S2). Compound 18 (C 16 H 12 F 4 N 2 OS, M = 356.06 g/mol) crystallized in the triclinic space group P-1, with a = 6.1547(9) Å, b = 9.6685(9) Å, c = 13.1109(10) Å, α = 85.211(7)°, β = 80.405(10)°, γ = 72.260(11)°, and V = 732.25(15) Å 3 , Z = 2, T = 150.00(10) K, μ (Cu Kα) = 2.474 mm –1 , and Dcalc = 1.616 g/cm 3 . A total of 4785 reflections were collected (6.842° ≤ 2θ ≤ 147.402°), 2849 of which were unique ( R int = 0.0563, R sigma = 0.0800).…”

Section: Resultsmentioning

confidence: 99%

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Unveiling FM-1088: A Breakthrough in Isoindolinone-Based Acaricide Development

Liu,

Gao,

Pei

et al. 2024

J. Agric. Food Chem.

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The increasing resistance of agricultural pests to existing acaricides presents a significant challenge to sustainable agriculture. Therefore, this study introduced FM-1088, a novel isoindolinone-based phenyl trifluoroethyl thioether derivative generated through an innovative design strategy combining bioisosterism and novel cyclization methods. We synthesized several compounds and evaluated their acaricidal efficacy against Tetranychus cinnabarinus in greenhouses and Panonychus citri in field settings. FM-1088 emerged as a standout candidate, demonstrating a lower median lethal concentration (LC 50 ) of 0.722 mg/L compared to the commercial acaricide, cyetpyrafen. Notably, 30 days after application, FM-1088 showed a field control efficacy of 96.4% against P. citri, highlighting its potential for broader applications. The results underscore the utility of the isoindolinone scaffold in pesticide development, offering a promising solution to combat pest resistance with implications for enhanced crop protection and agricultural productivity. Future studies should explore the detailed mode of action of FM-1088 and its potential applicability across diverse agricultural settings, further confirming its role as a sustainable solution for pest management.

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Section: Resultsmentioning

confidence: 99%

“…S1 and S2). 40 1 presents the bioassay results, demonstrating that most of the target compounds significantly inhibited T. cinnabarinus in the greenhouse. LC 50 values of highly active compounds are shown in Table 2.…”

Section: ■ Density Functional Theory Analysismentioning

confidence: 99%