The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway

Liang, Yuxi; Liu, Xiaoli; Hu, Jingyan; Huang, Songli; Ma, Xin; Liu, Xiaoyan; Wang, Rufeng; Hu, Xiuhua

doi:10.1016/j.jep.2022.115743

Cited by 5 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trollius chinensis Bunge, a perennial herb of the Ranunculaceae family, falls under the genus Trollius [ 1 ]. Widely distributed in Northern China, T. chinensis is recognized for its high ornamental and medicinal value [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…T. chinensis , with its significant ornamental and health-related compounds, is highly esteemed for applications in the food, medicine, and cosmetic industries [ 7 ]. Traditionally, the Chinese have employed T. chinensis for medicinal and tea purposes, dating back to the Qing Dynasty and recorded in Supplements to the Compendium of Materia Medica (Qing Dynasty) as “bitter in taste, cold in nature, non-toxic, mainly used for heat-clearing and detoxicating” [ 1 , 7 ]. It holds a prominent place in pharmacies, is frequently referenced in medical literature, and is listed in the Chinese Pharmacopoeia (Edition 2020) with five Chinese patent medicines.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the flavonoid metabolite(s) Orientin and poncirin found in T. chinensis exhibited significant antiviral activity against parainfluenza type 3 (Para 3) [10]. Additionally, researchers have identified seventeen new labdane diterpenoid glycosides A-Q (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) in the dried flowers of T. chinensis, possessing therapeutic, antiviral, and antibacterial properties, establishing T. chinensis as a common anti-inflammatory drug and health tea [14,15]. The flowers have traditional uses in treating respiratory infections, pharyngitis, tonsillitis, and bronchitis in Chinese medicine [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trollius chinensis Bunge: A Comprehensive Review of Research on Botany, Materia Medica, Ethnopharmacological Use, Phytochemistry, Pharmacology, and Quality Control

He,

Wang,

et al. 2024

Molecules

View full text Add to dashboard Cite

Trollius chinensis Bunge, a perennial herb belonging to the Ranunculaceae family, has been extensively used in traditional Chinese medicine. Documented in the Supplements to the Compendium of Materia Medica, its medicinal properties encompass a spectrum of applications, including heat clearance, detoxification, alleviation of oral/throat sores, earaches, eye pain, cold-induced fever, and vision improvement. Furthermore, T. chinensis is used in clinical settings to treat upper respiratory infections, pharyngitis, tonsillitis, esoenteritis, canker, bronchitis, etc. It is mainly used to treat inflammation, such as inflammation of the upper respiratory tract and nasal mucosa. This comprehensive review explores the evolving scientific understanding of T. chinensis, covering facets of botany, materia medica, ethnopharmacological use, phytochemistry, pharmacology, and quality control. In particular, the chemical constituents and pharmacological research are reviewed. Polyphenols, mainly flavonoids and phenolic acids, are highly abundant among T. chinensis and are responsible for antiviral, antimicrobial, and antioxidant activities. The flower additionally harbors trace amounts of volatile oil, polysaccharides, and other bioactive compounds. The active ingredients of the flower have fewer side effects, and it is used in children because of its minimal side effects, which has great research potential. These findings validate the traditional uses of T. chinensis and lay the groundwork for further scientific exploration. The sources utilized in this study encompass Web of Science, Pubmed, CNKI site, classic monographs, Chinese Pharmacopoeia, Chinese Medicine Dictionary, and doctoral and master’s theses.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trollius chinensis Bunge: A Comprehensive Review of Research on Botany, Materia Medica, Ethnopharmacological Use, Phytochemistry, Pharmacology, and Quality Control

He,

Wang,

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…TCB has a bitter flavor and is non-toxic. TCB is the main treatment for mouth sores, throat swelling, floating heat tooth Xuan, earache, eye pain, bright eyes, and solving the Arashi barrier [ 4 ]. In addition, TCB’s principal uses are for treating respiratory tract infections, namely, pharyngitis, tonsillitis, and bronchitis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Research Review of Herbal Textual Research, Phytochemistry, Pharmacology, Traditional Uses, Clinical Application, Safety Evaluation, and Quality Control of Trollius chinensis Bunge

Yang,

Wang,

Wang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Trollius chinensis Bunge (TCB) is a perennial plant of the Ranunculaceae family with medicinal and edible values. It is widely distributed and commonly used in various regions, including Asia, Europe, and North America. The main chemical components of TCB include alkaloids, flavonoids, phenolic acids, and volatile oil compounds. TCB is renowned for its anti-inflammatory, heat-clearing, detoxifying, and eyesight-improving properties. Its dried flowers are commonly used as a traditional Chinese medicine indicated for the treatment of upper respiratory tract infections, chronic tonsillitis, pharyngitis, influenza, and bronchitis. Modern pharmacology has demonstrated the anti-cancer, anti-inflammatory, antihypertensive, and antioxidant effects of TCB. This study presents a comprehensive overview of various aspects of TCB, including herbal textual research, botany, phytochemistry, pharmacology, traditional uses, clinical application, and quality control, aiming to provide new ideas on the scientific application of TCB as well as the integration of modern research with traditional medicinal uses.

show abstract

“…More recent molecular chemistry research has demonstrated that Trollius is rich in flavonoids and alkaloids [11]. Additionally, its medical efficacy in antiviral and antioxidant properties has been confirmed in the context of pharmacology [10,12]. Due to their medical value, the resource of Trollius species has been over-harvested anthropogenically and their populations have dwindled dramatically.…”

Section: Introductionmentioning

confidence: 99%

Impacts of Climate Change on the Distribution of Suitable Habitats and Ecological Niche for Trollius Wildflowers in Ili River Valley, Tacheng, Altay Prefecture

Fan,

Luo

2024

Plants

View full text Add to dashboard Cite

Xinjiang in China is distinguished by its distinctive regional landscape and high ecological sensitivity. Trollius wildflowers represent a unique and iconic element of the mountain flower landscape in Xinjiang. However, their populations are predominantly distributed in mountainous areas, making them susceptible to climate change. Despite this, the impacts of climate change on the distribution of suitable habitats and ecological niche differentiation for Trollius wildflowers have rarely been quantified. Consequently, simulations were conducted using the R-optimized MaxEnt model to predict the suitable habitat distribution of Trollius wildflowers. This was based on the occurrence data and environmental variables for the four species of Trollius (T. altaicus, T. asiaticus, T. dschungaricus, and T. lilacinus) that exist in the study area. The simulation was conducted over a period of time, beginning with the past glacial period and extending to the present, and then to the future (2050s, 2070s, and 2090s) under multiple scenarios (SSP1-2.6, SSP3-7.0, SSP5-8.5). The simulation of suitable habitats enabled the measurement of the ecological niche breadth and differentiation. The results demonstrate that the model predictions are precisely accurate, with AUC values exceeding 0.9. Annual mean temperature (Bio1), isothermality (Bio3), and precipitation in the warmest quarter (Bio18) are the dominant climate variables, in addition to vegetation, elevation, and soil factors. The proportion of suitable habitats for Trollius wildflowers varies considerably over time, from 0.14% to 70.97%. The majority of habitat loss or gain occurs at the edges of mountains, while stable habitats are concentrated in the core of the mountains. The gravity center of suitable habitats also shifts with spatial transfer, with the shifts mainly occurring in a northeasterly–southwesterly direction. The SSP1-2.6 scenario results in the sustained maintenance of habitats, whereas the SSP3-7.0 and SSP5-8.5 scenarios present challenges to the conservation of habitats. The threshold of ecological niche breadth for Trollius wildflowers is subject to fluctuations, while the ecological niche differentiation also varies. The study aims to examine the evolution of the habitat and ecological niche of Trollius wildflowers in Xinjiang under climate change. The findings will provide theoretical support for delineating the conservation area, clarify the scope of mountain flower tourism development and protection of mountain flower resources, and promote the sustainable development of ecotourism and effective utilization of territorial space in Xinjiang.

show abstract

The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway

Cited by 5 publications

References 38 publications

Trollius chinensis Bunge: A Comprehensive Review of Research on Botany, Materia Medica, Ethnopharmacological Use, Phytochemistry, Pharmacology, and Quality Control

Trollius chinensis Bunge: A Comprehensive Review of Research on Botany, Materia Medica, Ethnopharmacological Use, Phytochemistry, Pharmacology, and Quality Control

A Comprehensive Research Review of Herbal Textual Research, Phytochemistry, Pharmacology, Traditional Uses, Clinical Application, Safety Evaluation, and Quality Control of Trollius chinensis Bunge

Impacts of Climate Change on the Distribution of Suitable Habitats and Ecological Niche for Trollius Wildflowers in Ili River Valley, Tacheng, Altay Prefecture

Contact Info

Product

Resources

About