The crosstalk between Wnt/β-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy

Karimaian, Ansar; Majidinia, Maryam; Baghi, Hossein Bannazadeh; Yousefi, Bahman

doi:10.1016/j.dnarep.2017.01.003

Cited by 100 publications

(74 citation statements)

References 51 publications

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“…An efficient DNA repair mechanism is required to maintain genomic instability in mammalian cells exposed to environmental stresses (Karimaian et al . ). Coincidently, three of our candidate genes ( NPM1 , EIF2AK4 and MTOR ) have roles related to DNA damage repair.…”

Section: Resultsmentioning

confidence: 97%

Genome‐wide scan reveals divergent selection among taurine and zebu cattle populations from different regions

Edea

Dadi

Dessie³

et al. 2018

Animal Genetics

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In this study, to identify genomic signatures of divergent selection, we genotyped 10 cattle breeds/populations (n = 275), representing eight Ethiopian cattle populations (n = 229) and two zebu populations (n = 46) adapted to tropical and sub-tropical environments, using the high-density single-nucleotide polymorphisms (SNPs) derived mainly from Bos indicus breeds, and using five reference taurine breeds (n = 212). Population genetic differentiation (F ST ) values across sliding windows were estimated between zebu and reference combined taurine breeds. The most differentiated regions (F ST ≥ 0.53), representing the top 1% smoothed F ST values, were considered to represent regions under diversifying selection. In total, 285 and 317 genes were identified in the comparisons of Ethiopian cattle with taurine and Asian zebu with taurine respectively. Some of these genes are involved in stress responses/thermo-tolerance and DNA damage repair (HSPA4, HSF1, CMPK1 and EIF2AK4), pigmentation (ERBB3 and MYO1A), reproduction/fertility (UBE2D3, ID3 and PSPC1), immune response (PIK3CD and AKIRIN2) and body stature and size (MBP2, LYN and NPM1). Additionally, the candidate genes were associated with functional terms (e.g. cellular response to stress, DNA repair, inflammatory response) important for physiological adaptation to environmental stresses. The results of our study may shed light on the influence of artificial and natural selection in shaping the genomic diversity of modern cattle breeds and also may serve as a basis for further genetic investigation of traits of tropical adaptation in cattle.

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Section: Resultsmentioning

confidence: 97%

Genome‐wide scan reveals divergent selection among taurine and zebu cattle populations from different regions

Edea

Dadi

Dessie³

et al. 2018

Animal Genetics

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“…However, in the case of XRCC1, the results are very controversial. Some researchers have showed a link between the XRCC1 R194W allele and breast cancer [43,[61][62][63], while others have reported no such association [13,[64][65][66][67], and one group found a decreased breast cancer risk associated with this allele [68]. Similarly, XRCC1 R280H has been associated with breast cancer in one report [13], but not in others [63,13].…”

Section: Base Excision Repair (Ber) Pathwaymentioning

confidence: 92%

DNA repair and damage pathways in breast cancer development and therapy

Majidinia

Yousefi

2017

DNA Repair

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“…The CRISPR-Cas9/gRNA system makes the genome editing process in two ways: (a) NHEJ: Cas9 cut double-strand DNA and creates a double-strand break. Double strand breaks (DBSs) are repaired by NHEJ (Karimaian, Majidinia, Bannazadeh Baghi, & Yousefi, 2017;Majidinia & Yousefi, 2016a, 2016bMajidinia et al, 2017). The NHEJ may have an error in the repair process and, at the DBS site, an/a insertion/deletion occurs that causes frameshifts or premature stop codons, which ultimately leads to the destruction of the open reading frame of the target gene.…”

Section: Genome Editingmentioning

confidence: 99%

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

Karimian

Azizian

Parsian

et al. 2019

Journal Cellular Physiology

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Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9 (CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous characteristics in comparison with the conventional methods (e.g., zinc finger nucleases and transcription activator‐like effector nucleases) such as cost‐effectiveness, flexibility, and being easy‐to‐use. Despite some limitations such as efficient delivery and safety, CRISPR‐Cas9 is still the most convenient tool for gene editing purposes. Due to the potential capability of the CRISPR‐Cas9 system in genome editing and correction of casual mutations, it can be considered as a possible therapeutic system in the treatment of disorders associated with the genome mutations and in particular cancer treatment. In this review, we will discuss CRISPR‐Cas‐based gene editing along with its classifications and mechanism of action. Furthermore, the therapeutic application of the CRISPR‐Cas9 system in mutational disorders, delivery systems, as well as its advantages and limitations with a special emphasis on cancer treatment will be discussed.

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The crosstalk between Wnt/β-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy

Cited by 100 publications

References 51 publications

Genome‐wide scan reveals divergent selection among taurine and zebu cattle populations from different regions

Genome‐wide scan reveals divergent selection among taurine and zebu cattle populations from different regions

DNA repair and damage pathways in breast cancer development and therapy

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

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