The “crosstalk” between microbiota and metabolomic profile in high-fat-diet-induced obese mice supplemented with Bletilla striata polysaccharides and composite polysaccharides

Zhang, Qian; Zeng, Rui; Tang, Junni; Jiang, Xiaole; Zhu, Chenglin

doi:10.1016/j.ijbiomac.2024.130018

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…The preparation of fecal and milk samples for 1 H-NMR analysis followed the methods outlined by Zhu et al (2021) and Zhang et al (2024) . Briefly, fecal samples were processed for 1 H-NMR analysis by vortex mixing 80 mg of stool with 1 mL of deionized water for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Microbiome and metabolome analyses of milk and feces from dairy cows with healthy, subclinical, and clinical mastitis

Zhu,

Zhao,

Yang

et al. 2024

Front. Microbiol.

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Mastitis is commonly recognized as a localized inflammatory udder disease induced by the infiltration of exogenous pathogens. In the present study, our objective was to discern fecal and milk variations in both microbiota composition and metabolite profiles among three distinct groups of cows: healthy cows, cows with subclinical mastitis and cows with clinical mastitis. The fecal microbial community of cows with clinical mastitis was significantly less rich and diverse than the one harbored by healthy cows. In parallel, mastitis caused a strong disturbance in milk microbiota. Metabolomic profiles showed that eleven and twenty-eight molecules exhibited significant differences among the three groups in feces and milk, respectively. Similarly, to microbiota profile, milk metabolome was affected by mastitis more extensively than fecal metabolome, with particular reference to amino acids and sugars. Pathway analysis revealed that amino acids metabolism and energy metabolism could be considered as the main pathways altered by mastitis. These findings underscore the notable distinctions of fecal and milk samples among groups, from microbiome and metabolomic points of view. This observation stands to enhance our comprehension of mastitis in dairy cows.

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Section: Methodsmentioning

confidence: 99%

Microbiome and metabolome analyses of milk and feces from dairy cows with healthy, subclinical, and clinical mastitis

Zhu,

Zhao,

Yang

et al. 2024

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The preparation of fecal and milk samples for 1 H-NMR analysis followed the methods outlined by Zhu et al (2021) and Zhang et al (2024). Briefly, fecal samples were processed for 1 H-NMR analysis by vortex mixing 80 mg of stool with 1 mL of deionized water for 5 min.…”

Section: Metabolome Analysismentioning

confidence: 99%

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Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Pi,

Fang,

et al. 2024

Nutrients

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The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds of millions of years. Over the past decade, a growing body of knowledge has underscored the intricate connections among diet, gut microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, and fungi have diverse biological functions including antioxidant, immunoregulatory, and metabolic activities. Their effects are closely tied to the gut microbiota, which metabolizes BPs into health-influencing compounds. Understanding how BPs and gut microbiota interact is critical for harnessing their potential health benefits. This review provides an overview of the human gut microbiota, focusing on its role in metabolic diseases like obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. It explores the basic characteristics of several BPs and their impact on gut microbiota. Given their significance for human health, we summarize the biological functions of these BPs, particularly in terms of immunoregulatory activities, blood sugar, and hypolipidemic effect, thus providing a valuable reference for understanding the potential benefits of natural BPs in treating metabolic diseases. These properties make BPs promising agents for preventing and treating metabolic diseases. The comprehensive understanding of the mechanisms by which BPs exert their effects through gut microbiota opens new avenues for developing targeted therapies to improve metabolic health.

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The “crosstalk” between microbiota and metabolomic profile in high-fat-diet-induced obese mice supplemented with Bletilla striata polysaccharides and composite polysaccharides

Cited by 3 publications

References 69 publications

Microbiome and metabolome analyses of milk and feces from dairy cows with healthy, subclinical, and clinical mastitis

Microbiome and metabolome analyses of milk and feces from dairy cows with healthy, subclinical, and clinical mastitis

Data_Sheet_1.docx

Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

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