The crossroads of the hypercoagulability and patient outcomes in osteoarthritis: interactions and connections

Abstract

Background Our study aimed to probe whether coagulation indices are linked to patient-reported outcomes (PROs) in OA. Methods A thorough review of the literature on OA and coagulation indices was conducted using bibliometric approaches. Clinical data were retrospectively analyzed in OA patients (7,068) and healthy controls (HC, 795). Coagulation indices—prothrombin time (PT), fibrinogen (FIB), activated partial thromboplastin time (APTT), thrombin time (TT), D-dimer, and platelet count (PLT)—as well as immune-inflammatory indices, PROs (visual analogue scale and Short Form 36), were analyzed for correlations. Results Co-cited literature revealed that research related to OA and coagulation indices focused on inflammation, pain, and clinical utility. The levels of PLT, TT, FIB, and D-dimer were elevated in the OA group compared to the HC group. Hypercoagulable states are present in the OA. The results of the ROC demonstrate that they can differentiate between OA and healthy individuals. Coagulation indices were strongly linked to immune-inflammatory indicators and PROs. Logistic regression analysis indicated that PLT, D-dimer, and C-reactive protein (CRP) were all predictive of disease activity. However, PLT and D-dimer combined with CRP had a superior predictive effect than CRP alone. Conclusion PLT and D-dimer may serve as appropriate biomarkers to correlate with OA disease activity.