The crosslinking theory of aging — Added evidence

Bjorksten, Johan; Tenhu, Heikki

doi:10.1016/0531-5565(90)90039-5

Cited by 50 publications

(28 citation statements)

References 9 publications

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“…Our findings are consistent with and supported by the underlying error damage theory of aging (Bjorksten, ; Bjorksten & Tenhu, ; Jin, ). Given this theory, we would predict that Ps would accumulate with age of an organism as demonstrated with cormorants in this study.…”

Section: Discussionsupporting

confidence: 91%

“…One proposed mechanism of the error‐damage theory includes the cross‐linking theory (Davidovic et al., ; Jin, ). This theory suggests that cells and tissues are damaged by an accumulation of cross‐linked proteins, slowing down bodily processes and resulting in aging (Bjorksten, ; Bjorksten & Tenhu, ; Jin, ). A major category of these cross‐linked proteins are compounds called advanced glycation end products (AGEs) (Cerami, Vlassara, & Brownlee, ).…”

Section: Introductionmentioning

confidence: 99%

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Using pentosidine and hydroxyproline to predict age and sex in an avian species

Dorr

Stahl

Hanson‐Dorr

et al. 2017

Ecology and Evolution

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All living organisms are subject to senescence accompanied by progressive and irreversible physiological changes. The error damage and cross‐linking theories suggest that cells and tissues are damaged by an accumulation of cross‐linked proteins, slowing down bodily processes and resulting in aging. A major category of these cross‐linked proteins are compounds called advanced glycation end products (AGEs). We investigated the relationship between accumulation of the AGE, pentosidine (Ps), and hydroxyproline (HYP) a post‐translationally modified amino acid, with age, sex, and breeding status (breeder/nonbreeder) from skin samples of known age (i.e., banded as fledglings), free‐ranging Double‐crested Cormorants (Phalacrocorax auritus, Lesson 1831). We developed multivariate models and evaluated the predictive capability of our models for determining age and breeding versus nonbreeding birds. We found significant relationships with Ps and HYP concentration and age, and Ps concentration and sex. Based on our two‐class model using Ps and HYP as explanatory variables, we were able to accurately determine whether a cormorant was a breeder or nonbreeder in 83.5% of modeled classifications. Our data indicate that Ps and HYP concentrations can be used to determine breeding status of cormorants and potentially age of cormorants although sex‐specific models may be necessary. Although the accumulation of Ps explained the greatest amount of variance in breeding status and age, importantly, Ps covaried with HYP and combined improved prediction of these demographics in cormorants. Our data support the error damage and cross‐linking theories of aging. Both Ps and HYP increase predictably in cormorants and are predictive of age and breeding status. Given the ubiquity of these biomarkers across taxa, their use in estimating demographic characteristics of animals could provide a powerful tool in animal ecology, conservation, and management.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Using pentosidine and hydroxyproline to predict age and sex in an avian species

Dorr

Stahl

Hanson‐Dorr

et al. 2017

Ecology and Evolution

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“…Following aging, collagen in the skin cross link closely to decrease the elasticity of skin, meanwhile, the content of hydroxyproline is low. So, hydroxyproline in the skin could reflect the skin senescence [4][5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture and moxibustion on MDA, GSH-Px, and hyp in the skin of senile mice

Yang¹,

Xu²,

Sun³

2011

J. Acupunct. Tuina. Sci.

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【Abstract】Objective: To observe the effects of acupuncture and moxibustion on the skin histomorphology of senile mice. Methods: The subacute senile model of mouse was made by subcutaneous injection of D-galactose into the neck, then they were randomly allocated into an acupuncture group, a moxibustion group, a model group, and a blank group, and measured the content of malondialdehyde (MDA), activity of glutathione peroxidase (GSH-Px), and content of hydroxyproline (Hyp) in the skin tissue.

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“…The rate of living theory puts across the idea that organisms that metabolize oxygen more rapidly have a higher energy expenditure and typically have shorter lifespans that can be extended by caloric restriction [10], [11], [12], [13]. According to the cross-linking (or glycosylation) theory of aging, cross-linked proteins or sugar moieties can bind to DNA causing replicative damage or an age-related decline in protein turnover that can be linked to the loss of functional proteins, further promoting age-associated pathologies [14].…”

Section: Biological Theories Of Agingmentioning

confidence: 99%

Redox control of senescence and age-related disease

2017

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The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases. Finally, we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.

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The crosslinking theory of aging — Added evidence

Cited by 50 publications

References 9 publications

Using pentosidine and hydroxyproline to predict age and sex in an avian species

Using pentosidine and hydroxyproline to predict age and sex in an avian species

Effects of acupuncture and moxibustion on MDA, GSH-Px, and hyp in the skin of senile mice

Redox control of senescence and age-related disease

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