The cross-talk modulation of excited state electron transfer to reduce the false negative background for high fidelity imaging <i>in vivo</i>

Jiang, Ao; Liu, Yuxia; Chen, Guang; Li, Yong; Tang, Bo

doi:10.1039/c9sc05765j

Cited by 17 publications

(4 citation statements)

References 38 publications

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“…Over the past several years, electrochemical analysis, chromogenic detection, and gas chromatography have been widely reported in detecting CO. − Despite desirable sensitivity, they are unfit for detection of CO in living systems, owing to the complicated pretreatment and potential destruction of biological samples. Recently, fluorescent probes have been widely applied for imaging of various analytes in living cells, tissues, and organisms due to their simple operation and little biodamage. − So far, many CO probes have been successfully designed by researchers, but most of them are turn-on types, which could suffer from a range of factors including the concentration of probe, pH, temperature, instrument efficiency, etc. − For example, Feng et al developed an allyl-chloroformate-functionalized turn-on fluorescent probe based on fluorescein for CO in living cells (Figure A) . By contrast, a fluorescent probe with ratiometric character can overcome these problems effectively by self-calibration via two emission bands.…”

Section: Introductionmentioning

confidence: 99%

Construction of NIR and Ratiometric Fluorescent Probe for Monitoring Carbon Monoxide under Oxidative Stress in Zebrafish

et al. 2021

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Carbon monoxide (CO), as a crucial gasotransmitter, is endogenously produced by the degradation of heme and plays a critical role in regulating various physiological and pathophysiological processes such as oxidative stress. Thus, an effective fluorescent probe for investigating the relationships between CO and oxidative stress in vivo is necessary. In this paper, a ratiometric near-infrared (NIR) fluorescent probe (CP-CO) based on a coumarin-benzopyran fluorophore for imaging CO is developed. CP-CO itself displays strong coumarin emission due to its spironolactone structure. After the probe is reacted with CO and PdCl 2 , a notable enhancement of emission intensity at 690 nm can be found, which results in an obvious red shift of emission (200 nm). Moreover, CP-CO exhibits high sensitivity toward CO and produces a high enhancement ratio (203-fold). In addition, the probe is applied for ratiometric monitoring of exogenous and endogenous CO levels in HepG2 cells. Furthermore, the fluorescence imaging of CP-CO in zebrafish is performed by twophoton excitation along with excellent penetration ability. Most importantly, CP-CO can visualize the upregulation of CO under lipopolysaccharide (LPS)-induced oxidative stress in a zebrafish model, which vividly reveals its excellent ability in the elucidation of CO function in related biological events.

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Section: Introductionmentioning

confidence: 99%

Construction of NIR and Ratiometric Fluorescent Probe for Monitoring Carbon Monoxide under Oxidative Stress in Zebrafish

et al. 2021

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“…A promising method to sensitively detect Cys is utilizing reaction-based probes that couple fluorescent enhancement with analyte-associated reactivity. − In the context of Cys sensing, a variety of reaction-based fluorescent probes have been developed. − However, the emission of current probes mainly fall into the visible region, greatly hindering their practical in vivo application. − Until now, for noninvasive visualization in mammalian tissue, near-infrared (NIR) fluorescent probes − have attracted great attention because of their minimal background and deep-tissue penetration. , Another bottleneck encountered with most reported probes is critically limited by the response rate of Cys. − Because of the transient endogenous generation of cellular Cys, , the slow response characteristic (especially for NIR probes) seriously retards the application in real-time imaging of Cys-related biological processes . Thus, we sought that an ideal Cys probe is simultaneously endowed with (i) rapid response; (ii) low detection limit; and (iii) long-wavelength in NIR region.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Near-Infrared Cyanine-Based Fluorescent Probes for Rapid In Vivo Sensing Cysteine

Zhang

Yan

et al. 2020

ACS Appl. Bio Mater.

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Cysteine (Cys) is well-known to be an important biothiol and related to many diseases. However, the in situ trapping of endogenous Cys is still handicapped by a lack of straightforward methods combined with long-wavelength emission and high-performance response. In this work, we described the rational design strategy of cyanine-based near-infrared (NIR) probes for the rapid detection of mitochondrial Cys in living cells and mice. We focus on how to improve the response rate via regulating the electron density of the recognition units in probes. The obtained three probes all displayed remarkable fluorescence enhancement at 780 nm. From screening the obtained probes, it was found that the probe Cy-S-diOMe with electron-donating recognition unit displayed the fastest response rate, the lowest detection limit, and the highest signal-to-noise ratio. More importantly, Cy-S-diOMe was successfully applied to monitor Cys in tumor-bearing mice (within merely 5 min). This paradigm by modulation of the response rate in the cyanine dyes provides a promising methodology for the design of high-performance cyanine-based NIR probes.

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“…Compared with current commercial cathode materials, Lirich layered oxides (LLOs) have become the most promising candidate cathode materials for high-energy Li-ion batteries (LIBs) because of their high capacity (up to 250 mAh g −1 ) [1,2]. LLOs are generally believed to be composed of Li 2 MnO 3 and LiMO 2 (M = Ni, Co, Mn, etc), which are economically and environmentally attractive due to their high manganese content [3]. There are some differences from traditional cathode materials with regard to redox reaction: the superior specific capacity of LLOs originates from the redox reaction of transition metal (TM) ions and oxygen ions.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of uniform lattice cation/anion doping to improve structural and electrochemical performance stability for Li-rich cathode materials

Líu

Xiang

et al. 2020

Nanotechnology

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There has been extensive research into lithium-rich layered oxide materials as candidates for the nextgeneration of cathode materials in lithium-ion batteries, due to their high energy density and low cost; however, their poor cycle life and fast voltage fade hinder their large-scale commercial application. Here, we propose a novel cation/anion (Na + /PO 4 3-) co-doping approach to mitigate the discharge capacity and voltage fade of a Co-free Li 1.2 Ni 0.2 Mn 0.6 O 2 cathode. Our results show that the synergistic effect of cation/anion doping can promote long cycle stability and rate performance by inhibiting the phase transformation of the layered structure to a spinel or rock-salt structure and stabilizing the well-ordered crystal structure during long cycles. The co-doped sample exhibits an outstanding cycle stability (capacity retention of 86.7% after 150 cycles at 1 C) and excellent rate performance (153 mAh g −1 at 5 C). The large ionic radius of Na + can expand the Li slab to accelerate Li diffusion and the large tetrahedral PO 4 3polyanions with high electronegativity stabilize the local structure to improve the electrochemical performance.

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The cross-talk modulation of excited state electron transfer to reduce the false negative background for high fidelity imaging in vivo

Abstract: We engineered a cross-talk electron transfer strategy using an F–D–A system to reduce the false negative background for high fidelity imaging in vivo.

Cited by 17 publications

References 38 publications

Construction of NIR and Ratiometric Fluorescent Probe for Monitoring Carbon Monoxide under Oxidative Stress in Zebrafish

Construction of NIR and Ratiometric Fluorescent Probe for Monitoring Carbon Monoxide under Oxidative Stress in Zebrafish

Rational Design of Near-Infrared Cyanine-Based Fluorescent Probes for Rapid In Vivo Sensing Cysteine

Synergistic effect of uniform lattice cation/anion doping to improve structural and electrochemical performance stability for Li-rich cathode materials

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