The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia

Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena

“…), which itself could produce analgesia through activation of endogenous opioid and serotonergic systems (Yesilyurt et al . ), and thus confound interpretation of the results. One way to avoid this is by using running wheels placed in the animals’ home cages.…”

P2X3 receptor‐mediated visceral hyperalgesia and neuronal sensitization following exposure to PTSD‐like stress in the dorsal root ganglia of rats

“…ATP release and P2X3 receptor‐mediated nociceptive sensory nerve responses were enhanced in several animal models of visceral injury, including the urinary bladder and colon. This implies that P2X3 may play a pivotal role in the transmission of nociceptive signaling process …”

“…36,37,56 This model is also responsive to treatments that show some efficacy in alleviating visceral pain in IBS patients, and thus can be used to predict treatment responses to specific drugs or nonpharmacological interventions in humans. 5,57 Existing evidence indicates that females are more responsive to stress 58,59 and epidemiologic studies indicate two-thirds of IBS patients are female, and the prevalence of condition range from 14% to 24%. 60 Previous data highlighted the importance of sex-specific interventions to modulate visceral pain response to stress, and only females develop a delayed hyperalgesia in response to repeated water avoidance stress, revealing sex differences in psychological stress-induced delayed alterations of visceral sensitivity.…”

Transmission pathways and mediators as the basis for clinical pharmacology of pain

“…Using mice, Yesilyurt et al [163] investigated the role of serotonin receptors in stress-induced analgesia. After forcing mice to endure a stressor (swimming in cold water), tail flick response (indicative of pain) upon exposure to a hot plate was decreased [163].…”

“…After forcing mice to endure a stressor (swimming in cold water), tail flick response (indicative of pain) upon exposure to a hot plate was decreased [163]. Yesilyurt et al [163] further showed that both endogenous opioid and non-opioid effects played a role stress-induced analgesia. Specifically, when serotonin receptors were blocked in test subjects, the effect of stress-induced analgesia was observed to decrease.…”