The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection

Cheyuo, Cletus; Yang, Weng Lang; Wang, Haichao

doi:10.1515/hsz-2012-0103

Cited by 13 publications

(10 citation statements)

References 112 publications

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“…Administration of exogenous Adm and its binding protein has shown neuroprotective effects against brain injury in experimental disease models. 97,98 Edn3, a vasoconstrictor from the endothelin family, is known to induce NO production, promote angiogenesis, regulate synthesis of inflammatory mediators and glutamate transporters, and control fluid and electrolyte homeostasis in the brain. [99][100][101][102][103][104] This broad spectrum of vascular responses again suggests a potentially wide distribution of microvessel reactions to injury in the entire ipsilateral cortex after TBI.…”

Section: Differentially Expressed Genesmentioning

confidence: 99%

Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

Guo

Lok

Zhao

et al. 2016

Journal of Neurotrauma

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Perturbations in blood vessels play a critical role in the pathophysiology of brain injury and neurodegeneration. Here, we use a systematic genome-wide transcriptome screening approach to investigate the vasculome after brain trauma in mice. Mice were subjected to controlled cortical impact and brains were extracted for analysis at 24 h post-injury. The core of the traumatic lesion was removed and then cortical microvesels were isolated from nondirectly damaged ipsilateral cortex. Compared to contralateral cortex and normal cortex from sham-operated mice, we identified a wide spectrum of responses in the vasculome after trauma. Up-regulated pathways included those involved in regulation of inflammation and extracellular matrix processes. Decreased pathways included those involved in regulation of metabolism, mitochondrial function, and transport systems. These findings suggest that microvascular perturbations can be widespread and not necessarily localized to core areas of direct injury per se and may further provide a broader gene network context for existing knowledge regarding inflammation, metabolism, and blood-brain barrier alterations after brain trauma. Further efforts are warranted to map the vasculome with higher spatial and temporal resolution from acute to delayed phase post-trauma. Investigating the widespread network responses in the vasculome may reveal potential mechanisms, therapeutic targets, and biomarkers for traumatic brain injury.

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Section: Differentially Expressed Genesmentioning

confidence: 99%

Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

Guo

Lok

Zhao

et al. 2016

Journal of Neurotrauma

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“…Adrenomedullin (ADM) is a member of the calcitonin gene-related peptide (CGRP) family, which has shown neuroprotective functions [45]. ADM is secreted in many organs and tissues [46], and so were PC12 cells.…”

Section: Resultsmentioning

confidence: 99%

Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering

Yang

Chen

Chiang

et al. 2016

BioMed Research International

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The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. Hyaluronic acid (HA) biomaterial has been applied in a wide range of medical and biological fields and plays important roles in neural regeneration. PC12 cells have been reported to be capable of endogenous NGF synthesis and secretion. The purpose of this research was to assess the effect of HA biomaterial combining with PC12 cells conditioned media (PC12 CM) in neural regeneration. Using SH-SY5Y cells as an experimental model, we found that supporting with PC12 CM enhanced HA function in SH-SY5Y cell proliferation and adhesion. Through RP-nano-UPLC-ESI-MS/MS analyses, we identified increased expression of HSP60 and RanBP2 in SH-SY5Y cells grown on HA-modified surface with cotreatment of PC12 CM. Moreover, we also identified factors that were secreted from PC12 cells and may promote SH-SY5Y cell proliferation and adhesion. Here, we proposed a biomaterial surface enriched with neurotrophic factors for nerve regeneration application.

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“…However, there were limited region-specific decreases in microglial expression of certain genes. For example, C1–C3 cervical microglia demonstrated a reduced expression of Adm-2 and Vegf - genes whose products exert neuroprotective effects (Cheyuo et al, 2012; Rosenstein et al, 2010) and are directly upregulated by the hypoxia-sensitive transcription factor HIF-1 (hypoxia-inducible factor 1) (Shibuya, 2013; Zudaire et al, 2006). In contrast, in brainstem homogenates, Vegf mRNA levels increased.…”

Section: Discussionmentioning

confidence: 99%

“…insulin-like growth factor (IGF)-1 (Lalancette-Hebert et al, 2007) and BDNF (Coull et al, 2005)], and/or that are known to promote various forms of neuronal plasticity or neuroprotection [e.g. vascular endothelial growth factor (VEGF; Dale-Nagle et al, 2011; Storkebaum et al, 2004), BDNF (Numakawa, 2014; Parkhurst et al, 2013), IGF-1 (Benarroch, 2012; Deak and Sonntag, 2012), and adrenomedullin (ADM)-2 (Cheyuo et al, 2012)]. ADM-2 and VEGF are also highly hypoxia-responsive in other systems (via HIF activation) (Berra et al, 2000; Kaur et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS

Peters

Kimyon²,

Mitchell³

et al. 2015

Respiratory Physiology & Neurobiology

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Modest protocols of repetitive acute intermittent hypoxia (rAIH) enhance motor function in patients with chronic incomplete spinal injury. Since chronic intermittent hypoxia (CIH) elicits neuroinflammation, there is potential for rAIH to have similar effects. Thus, we tested the hypothesis that rAIH has minimal impact on microglial inflammatory gene expression, but up-regulates key neurotrophic factor expression in a CNS region-specific manner. Using real time PCR, we evaluated mRNA levels of inflammatory and neurotrophic factors in immunomagnetically-isolated microglia from rat frontal cortex, brainstem and upper and lower cervical spinal cord following rAIH (ten, 5-minute episodes, thrice weekly, 4 weeks). In agreement with our hypothesis, rAIH had no significant impact on microglial inflammatory gene expression in any region studied. On the other hand, neurotrophic factor expression was altered in a gene-and region-specific pattern. These results have important implications for the safety of rAIH as a potential therapy to enhance neuroplasticity and motor function in patients with spinal injury or other neurologic disorders.

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The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection

Cited by 13 publications

References 112 publications

Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering

Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS

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