The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective

Lattanzi, Annalisa; Maddalo, Danilo

doi:10.1089/crispr.2022.0002

Cited by 3 publications

(4 citation statements)

References 74 publications

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“…Programmable gene-editing tools have made significant advancements in treating diseases [reviewed in detail in Katti et al (2022a ); Lattanzi and Maddalo (2022 ); Awwad et al (2023 ); Li et al (2023a )]. Adoptive T-cell therapy is one area of cancer research where CRISPR systems have shown immense therapeutic potential.…”

Section: Crispr As a Potential Therapeutic Modality For Cancermentioning

confidence: 99%

“…Its cost-effectiveness, facile design, and high efficiency have enabled it a powerful and preferred gene editing tool with enormous potential in both basic research and drug discovery platform. This is particularly true in cancer research, as CRISPR has had a huge impact on our understanding of cancer biology and many phases of cancer drug development ( Yin et al, 2019 ; Long et al, 2021 ; Katti et al, 2022a ; Lattanzi and Maddalo, 2022 ). For instance, its fast and efficient genome alterations have uncovered novel cancer-specific gene mutations and enabled rapid screening to identify and validate potential drug targets, precise disease modeling, and development of cancer therapeutics ( Katti et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

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Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

Ravichandran,

Maddalo

2023

Front. Genet.

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The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system is a powerful tool that enables precise and efficient gene manipulation. In a relatively short time, CRISPR has risen to become the preferred gene-editing system due to its high efficiency, simplicity, and programmability at low costs. Furthermore, in the recent years, the CRISPR toolkit has been rapidly expanding, and the emerging advancements have shown tremendous potential in uncovering molecular mechanisms and new therapeutic strategies for human diseases. In this review, we provide our perspectives on the recent advancements in CRISPR technology and its impact on precision medicine, ranging from target identification, disease modeling, and diagnostics. We also discuss the impact of novel approaches such as epigenome, base, and prime editing on preclinical cancer drug discovery.

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Section: Crispr As a Potential Therapeutic Modality For Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

Ravichandran,

Maddalo

2023

Front. Genet.

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“…• Used for gene editing via RNA-guided DNA cleavage then repair at a target DNA site, allowing for specific corrections, alterations, additions, or deletions to the genome 145 …”

Section: Introductionmentioning

confidence: 99%

“…• Engineering gRNA can improve the system’s specificity, stability, and safety and expand their applications 145 …”

Section: Introductionmentioning

confidence: 99%

Breaking the mold with RNA—a “RNAissance” of life science

Jones,

Androsavich,

et al. 2024

npj Genom. Med.

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In the past decade, RNA therapeutics have gone from being a promising concept to one of the most exciting frontiers in healthcare and pharmaceuticals. The field is now entering what many call a renaissance or “RNAissance” which is being fueled by advances in genetic engineering and delivery systems to take on more ambitious development efforts. However, this renaissance is occurring at an unprecedented pace, which will require a different way of thinking if the field is to live up to its full potential. Recognizing this need, this article will provide a forward-looking perspective on the field of RNA medical products and the potential long-term innovations and policy shifts enabled by this revolutionary and game-changing technological platform.

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Applications of AI in Biomedical Genomics and Pharmaceuticals

Al-Remawi,

Rahem

2024

2024 2nd International Conference on Cyber Resilience (ICCR)

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The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective

Cited by 3 publications

References 74 publications

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

Breaking the mold with RNA—a “RNAissance” of life science

Applications of AI in Biomedical Genomics and Pharmaceuticals

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