The creation of an infrarenal aneurysm within the native abdominal aorta of swine

The amounts of alpha 1 antitrypsin protein are reduced in the vascular wall of the acutely dissected human ascending aorta☆

“…Atherosclerosis is the leading pathology of aneurysms of the descending aorta, but not of the ascending aorta [11]. Pathophysiologically, elastin and angiotensin II can induce abdominal aortic aneurysms in animal models [12,13]. However, little is known about the genesis of ascending aortic dissections.…”

Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta

“…Examples of studies using porcine aorta as a model for the human aorta comprise models of aortic coarctation (Hu et al, 2008), post-vagotomy remodeling (Sokolis et al, 2005), thoracic sympathectomy (Angouras et al, 2012), and models of abdominal aortic aneurysm (AAA) (Hynecek et al, 2007;Molacek et al, 2009;Houdek et al, 2013). Porcine models of AAA are used for the introduction of mesenchymal stem cells into aortic injury (Turnbull et al, 2011), simulation of ruptured AAA repair (Suk et al, 2012), testing of endovascular repair techniques (Lederman et al, 2014), and stent grafts (Saari et al, 2012).…”

Endovascular aneurysmal models at the external iliac artery of dogs

“…11 In addition, aneurysms in muscular arteries, such as the popliteal artery, include the disappearance of the internal elastic lamina, external elastic lamina, and smooth muscle cells, as well as neointimal thickening. 12 In the present study using the EIA, which is a muscular artery, only the BϩE group showed significant dilatation of the arterial diameter.…”

“…However, generating these models requires surgical stresses, such as an abdominal operation or blood vessel sutures and other complicated procedures. 11 Establishing an aneurysm model using simple and easy operative techniques is desirable to develop new endovascular treatment devices such as stent grafts. We developed an aneurysm model using the external iliac arteries (EIAs) of adult Beagles, a relatively large animal that we thought would be easy to handle, using simple and less-complicated endovascular procedures.…”