The creation of a brain atlas for image guided neurosurgery using serial histological data

Development of FMRI techniques for planning in functional neurosurgery for Parkinson’s disease

“…This technique serves as a method eliciting functional activations, which can serve as complimentary to in-vivo imaging techniques presented [10,2], as well atlas-based planning procedures [6,4,26,19,12]. Further testing will be required with a patients suffering from movement disorders in order to further evaluate the clinical possibilities for this technique.…”

“…To demonstrate how these fMRI techniques can be used with digital atlases the definition of the sensory thalamus defined in the atlas of [4] was extracted and warped to each subject. The atlas-to-subject warping procedure used, is the template based procedure used in [6].…”

“…Thus image processing and acquisition techniques have been developed to enhance visualization of these nuclei. Anatomical digital atlases derived from serial histological data [4,26] and print atlases [14,19,22] have been used to identify subcortical nuclei. Others have added functional or post-operative data to anatomical representations to help suggest target locations in the sensory thalamus [6,12] and the subthalamic nucleus [7,11,18,20].…”

Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression

“…These methods are limited, however, by the specific demographics of the atlas library at hand, and may be difficult to adapt to new datasets (for example, using a library of young healthy controls to segment a population suffering from a neurodegenerative disorder). Further, these methods are not easily used with atlases that are somehow unique or time consuming to develop (such as atlases derived from reconstructed serial histological data (42) or high-resolution magnetic resonance imaging data) (30). Instead of utilizing multiple input atlases, MAGeT Brain uses the variability inherent in any dataset in order to limit the number of manually labeled atlases required as input (37, 38).…”

Validation of MRI-based 3D digital atlas registration with histological and autoradiographic volumes: An anatomofunctional transgenic mouse brain imaging study

“…This approach has been taken previously by Yelnik et al (2007) using a linear transformation and by Dauguet et al (2007) using a nonlinear transformation. MR images have also previously been registered to 3D-reconstructed autoradiographic (Malandain et al, 2004) and histological data (Schormann et al, 1995;Chakravarty et al, 2006;Li et al, 2009). Similarly, we used our 3-step approach to register MRI data to the autoradiographic and histological volumes, to determine the reference volume (photographic, autoradiographic, or histological) that would result in the most suitable registration for reliable anatomofunctional analysis.…”