The Cranial Base in Trisomy 21

Roche, A. F.; Roche, P. J.; Lewis, Arthur B.

doi:10.1111/j.1365-2788.1972.tb01566.x

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…While not all of these differences have a direct effect on speech production, they offer a starting point for discussing speech production abilities in individuals with Down syndrome. For example, absent and/or reduced bone growth in the bones of the head and face has implications for attachment locations and support of muscles used during speech production (Frostad, Chleall, & Melosky, 1971; Kisling, 1966; Roche, Roche, & Lewis, 1972; Sanger, 1975). Poorly differentiated midface muscles and/or additional facial muscles may contribute to difficulties with articulation (Bersu, 1976, 1980).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of articulatory working space area in vowel production of adults with Down syndrome

Bunton

Leddy

2010

Clinical Linguistics & Phonetics

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Section: Introductionmentioning

confidence: 99%

An evaluation of articulatory working space area in vowel production of adults with Down syndrome

Bunton

Leddy

2010

Clinical Linguistics & Phonetics

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Contribution of magnetic resonance imaging to the knowledge of CNS malformations related to chromosomal aberrations

Tamraz

Rethoré²,

Iba-Zizen

et al. 1987

Hum Genet

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Twelve patients presenting with various clinico-pathological syndromes related to chromosomal diseases have been evaluated using magnetic resonance imaging. They include patients with trisomy 21, trisomy 18, trisomy 13, 4p-syndrome, 5p-syndrome, and 7p-syndrome. In all these patients karyotype studies were performed demonstrating the chromosomal aberrations. All patients were examined using magnetic resonance imaging to evaluate the head and neck malformations which may be specifically associated with their chromosomal anomaly. We were particularly interested in brain abnormalities and the morphological findings correlated with some pathologic anatomical findings. A review of the literature on neuropathological data is reported and compared with the in vivo anatomical results obtained using this highly anatomical non-ionising and non-invasive investigative procedure. Particular interest is paid to trisomy 21 in which all recognizable stereotyped morphological skull and brain malformations are depicted with magnetic resonance and some other malformations demonstrated such as the excessive forward bending and ascension of the brainstem which correlated well with a simian cephalic organization.

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Histological Investigation of the Palatine Bone in Prenatal Trisomy 21

Lauridsen

Hansen

Reintoft

et al. 2001

The Cleft Palate-Craniofacial Journal

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Histological examination demonstrated four different palatal phenotypes on the basis of the development of the horizontal part of the palatine bone: type I, palatine bone complete; type II, the mesial region of the horizontal part of the palatine bone is lacking; type III, complete absence of the horizontal part of the palatine bone; and type IV, auxiliary bones in the region of the transpalatine suture. This finding shows that different types of malformations may occur in the horizontal part of the palatine bone in human trisomy 21 fetuses.

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The Cranial Base in Trisomy 21

Cited by 3 publications

References 17 publications

An evaluation of articulatory working space area in vowel production of adults with Down syndrome

An evaluation of articulatory working space area in vowel production of adults with Down syndrome

Contribution of magnetic resonance imaging to the knowledge of CNS malformations related to chromosomal aberrations

Histological Investigation of the Palatine Bone in Prenatal Trisomy 21

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