The COVID-19 Community Research Partnership: Objectives, Study Design, Baseline Recruitment, and Retention

Abstract

The COVID-19 Community Research Partnership (CCRP) is a multisite surveillance platform designed to characterize the epidemiology of the SARS-CoV-2 pandemic. This manuscript describes the CCRP study design and methodology. The CCRP includes two prospective cohorts, one with six health systems in the mid-Atlantic and southern United States, and the other with six health systems in North Carolina. With enrollment beginning April 2020, sites invited persons within their healthcare systems as well as community members to participate in daily surveillance for symptoms of COVID-like illnesses, testing and risk behaviors. Participants with electronic health records were also asked to volunteer data access. Subsets of participants, representative of the general population and including oversampling of populations of interest, were selected for repeated at home serology testing. By October 2021, 65,739 participants (62,261 adult and 3,478 pediatric) were enrolled with 89% providing syndromic data, 74% providing EHR data, and 70% participating in one of two serology sub-studies. An average of 62% of participants completed a daily survey at least once a week, and 55% of serology kits were returned. The CCRP provides rich regional epidemiologic data and opportunities to more fully characterize the risks and sequelae of SARS-CoV-2 infection.

Self-Reported SARS-CoV-2 Vaccination Is Consistent with Electronic Health Record Data among the COVID-19 Community Research Partnership

“…The COVID-19 Community Research Partnership (CCRP) is a prospective, multi-site cohort syndromic COVID-19 surveillance study of a convenience sample of adults (18+ years) enrolled from April 2020 through June 2021 primarily through direct email outreach at 10 healthcare systems from the mid-Atlantic and southeastern United States ( , 14 March 2022) [ 11 ]. Data were collected via a secure, Health Insurance Portability and Accountability Act of 1996 (HIPAA)-compliant, online platform through March 2022.…”

Association between COVID‐19 and consistent mask wearing during contact with others outside the household—A nested case–control analysis, November 2020–October 2021

“…Participants were enrolled in the COVID‐19 CRP, a multi‐site prospective cohort study based in the mid‐Atlantic and southern United States. 24 Adults affiliated with 10 participating healthcare systems were invited to enroll in the study beginning in April 2020, including patients within health systems; some other community members also enrolled in the study after local advertising via the healthcare system website. Participants completed a daily electronic survey and gave permission to access their electronic health record (EHR) data.…”

Association between self-reported masking behavior and SARS-CoV-2 infection wanes from Pre-Delta to Omicron-predominant periods — North Carolina COVID-19 Community Research Partnership (NC-CCRP)

“…The NC CCRP 6 is a prospective, multi-site cohort COVID- 19 syndromic surveillance study of a convenience sample of adults enrolled at six NC healthcare systems from April 2020 through June 2021 ( http://www.covid19communitystudy.org/ ). Participants were recruited through patient portals, public websites, and community outreach.…”