The course of insomnia in Parkinson's disease

Zhu, Ke; Hilten, Jacobus J. van; Marinus, Johan

doi:10.1016/j.parkreldis.2016.09.010

Cited by 57 publications

(67 citation statements)

References 34 publications

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“…In contrast, clinical features of the disease (i.e. dopaminergic medications, motor status, and autonomic dysfunctions) were very slightly related to insomnia complaint with small effect sizes (Chung et al, ; Gjerstad et al, ; Kurtis et al, ; Ratti et al, ; Tholfsen et al, ; Zhu, van Hilten, & Marinus, ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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Objective To test the efficacy of cognitive behavioral therapy for insomnia (CBT‐i) in Parkinson's Disease (PD) and to evaluate its impact on indices of daytime and psychological functioning. Method Fifteen patients with insomnia disorder (ID) comorbid to PD were enrolled in a single‐case design with multiple baselines. Total wake time, sleep efficiency, and daytime sleepiness were recorded on a sleep diary. Self‐reported measures of insomnia, anxiety and depressive symptoms, health‐related quality of life, and psychological variables perpetuating ID were completed. All patients also underwent a clinical interview for ID diagnosis. Results CBT‐i was associated with significant changes in sleep variables and ID criteria. Significant positive treatment‐related effects were also noted for all indices of daytime and psychological functioning, and for variables perpetuating ID. All of these improvements were well maintained at 3‐month follow‐up. Conclusion CBT‐i is a promising therapeutic avenue for patients with PD.

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Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Motor symptoms that emerge overnight causing sleep fragmentation include tremor, dyskinesia, nighttime cramps, dystonia (9). Overnight non-motor symptoms that negatively affect sleep include nocturia, autonomic dysfunction and psychiatric symptoms (9, 10). Comorbid primary sleep disorders such as obstructive sleep apnea (OSA), rapid eye movement sleep behavior disorder (RBD), restless legs syndrome (RLS) or periodic limb movements of sleep (PLMS) contribute to sleep fragmentation as well (11).…”

Section: Introductionmentioning

confidence: 99%

“…Low doses of dopaminergic medications act on pre-synaptic D2 receptors, facilitating sleep and reducing wakefulness (9, 12, 13). In contrast, higher doses of dopaminergic medication act at post-synaptic D1 and D2 receptors, inhibiting sleep and increasing insomnia (9, 10, 14). Overall, chronic insomnia appears to increase with the duration of PD (5, 15).…”

Section: Introductionmentioning

confidence: 99%

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Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

Gros

Videnović

2017

Curr Sleep Medicine Rep

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Purpose of review Sleep disorders are among the most challenging non-motor features of Parkinson’s disease (PD) and significantly affect quality of life. Research in this field has gained recent interest among clinicians and scientists and is rapidly evolving. This review is dedicated to sleep and circadian dysfunction associated with PD. Recent findings Most primary sleep disorders may co-exist with PD; majority of these disorders have unique features when expressed in the PD population. Summary We discuss the specific considerations related to the common sleep problems in Parkinson’s disease including insomnia, rapid eye movement sleep behavior disorder, restless legs syndrome, sleep disordered breathing, excessive daytime sleepiness and circadian rhythm disorders. Within each of these sleep disorders, we present updated definitions, epidemiology, etiology, diagnosis, clinical implications and management. Furthermore, areas of potential interest for further research are outlined.

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“…This has primarily been the result of the definition of insomnia being used with more restrictive definitions, leading to lower estimates. Similarly, in PD, reported insomnia rates vary widely from 25% to 80%, partially because of the differences in insomnia definitions and sample characteristics (eg, population based vs. clinic based, PD severity) . We present data of insomnia in PD based on the definition of insomnia specific to each protocol.…”

Section: Prevalence Of Insomnia In Pdmentioning

confidence: 99%

Practical Evaluation and Management of Insomnia in Parkinson's Disease: A Review

Wallace

Wohlgemuth

Trotti

et al. 2020

Movement Disord Clin Pract

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Background Insomnia is one of the most common nonmotor features of Parkinson's disease (PD). However, there are few practical guidelines for providers on how to best evaluate and treat this problem. Methods and Findings This review was developed to provide clinicians with a pragmatic approach to assessing and managing insomnia in PD. Recommendations were based on literature review and expert opinion. We addressed the following topics in this review: prevalence of insomnia in PD, sleep–wake mechanisms, theoretical models of insomnia, risk factors, assessment, pharmacologic and nonpharmacologic treatments. Insomnia treatment choices may be guided by PD severity, comorbidities, and patient preference. However, there is limited evidence supporting pharmacotherapy and nonpharmacologic treatments of insomnia in PD. Conclusions We provide a pragmatic algorithm for evaluating and treating insomnia in PD based on the literature and our clinical experience. We propose personalized insomnia treatment approaches based on age and other issues. Gaps in the existing literature and future directions in the treatment of insomnia in PD are also highlighted.

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The course of insomnia in Parkinson's disease

Cited by 57 publications

References 34 publications

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

Practical Evaluation and Management of Insomnia in Parkinson's Disease: A Review

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