The course of idiopathic dilated cardiomyopathy in New Zealand.

Ikram, Hamid; Williamson, H. G.; Won, M.; Crozier, Ian; Wells, Elizabeth

doi:10.1136/hrt.57.6.521

Cited by 46 publications

(22 citation statements)

References 34 publications

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“…[4][5][6]8,9 Survival rates in the present study (ie, 78.6% in newly diagnosed patients and 75.7% in total patients) were similar to those in the studies conducted in the 1990s in which the proportion of asymptomatic patients (NYHA functional class I: 15-20%) was similar to this study. An interesting finding in the present nationwide Japanese study is that survival rates were not significantly different among general hospitals and university hospitals, regardless of their size.…”

Section: Discussionsupporting

confidence: 77%

“…Older age is also reported to predict poor prognosis. 1,4,6 Few previous reports showed a relationship between male sex and poor prognosis. In the present study, these 5 variables were independently related to prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Left ventricular dilatation, [4][5][6]17 lower LVEF, 2,5,6,17,18 and higher NYHA functional class 2,5,6,18 are relatively established predictors of poor prognosis. Older age is also reported to predict poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Most prior studies of the natural history and prognosis of IDC have been based on populations of selected patients from referral centers, [1][2][3][4][5][6][7][8][9] and therefore, on the basis of different levels of care and management, various prognoses would be expected. The clinical outcome and perception of prognostic factors in IDC is profoundly affected by a bias in patient selection.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan Results From a Nationwide Study

Miura

Matsumori

Nasermoaddeli

et al. 2008

Circ J

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan Results From a Nationwide Study

Miura

Matsumori

Nasermoaddeli

et al. 2008

Circ J

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“…Most invasive and noninvasive indicators of cardiac dysfunction [29][30][31][32][33][34][35][36][37] strongly correlate with outcome. In particular, a decreased LVEF is closely associated with mortality in patients with either idiopathic cardiomyopathy or ischemia.…”

Section: Prognostic Value Of H/mbmipp:h/mtl and Lvefmentioning

confidence: 99%

Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure

Sasaki

Mitani

Usui

et al. 2003

Circ J

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Methods Study PopulationSeventy-six patients (22 women, 54 men; mean age, 65± In the present study, the effectiveness of 123 I--methyliodophenyl pentadecanoic acid (BMIPP) single photon emission computed tomography (SPECT) for predicting cardiac death of patients with chronic heart failure was evaluated. Abnormalities of fatty acid metabolism are found in patients with chronic heart failure and BMIPP was developed as a tracer for scintigraphic assessment of myocardial fatty acid utilization. The study group comprised 74 patients with chronic heart failure with a left ventricular ejection fraction (LVEF) <45% on left ventriculography or radionuclide angiocardiography. They underwent both 201 Tl SPECT and BMIPP SPECT. The uptake of tracer was scored semiquantitatively from 0 (normal) to 4 (defect) in 20 segments and a total defect score (TDS) for all 20 segments was calculated. On planar images the mediastinum to heart count ratio (H/M) was calculated for the BMIPP and Tl studies, and the H/MBMIPP:H/MTl (H/MBMIPP divided by H/MTl) was also calculated. The mean follow-up period was 660 days and there were 17 cases of cardiac death. Multivariate analysis identified H/MBMIPP:H/MTl (p<0.05) and LVEF (p<0.05) as independent predictors of cardiac death. The receiver-operating characteristic curve of H/MBMIPP:H/MTl was situated to the left relative to LVEF. Analysis of the myocardial metabolism by BMIPP SPECT can predict the high-risk patients with chronic heart failure. (Circ J 2003; 67: 918 -924)

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Determinants of end‐stage idiopathic dilated cardiomyopathy: A multivariate analysis of 104 patients

Romeo¹,

Pelliccia²,

Cianfrocca³

et al. 1989

Clinical Cardiology

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Summary:Our purpose in this study was to investigate the correlation of clinical, electrocardiographic, hemodynamic, and histopathologic features at diagnosis with the long-term prognosis in 104 patients with idiopathic dilated cardiomyopathy to determine which factors are the independent determinants of the end-stage disease. During a mean follow-up of 3.8rfr3.5 years, 35 patients (33%) died, 14 (13%) suddenly and 21 (20%) from congestive heart failure. Univariate analysis of survival curves disclosed that clinical and electrocardiographic variables at diagnosis were similar in survivors and nonsurvivors. On the contrary, patients who subsequently died had higher mean right atrial pressure (p=O.OOOl), right ventricular end-diastolic pressure (p =0.0061), mean pulmonary artery pressure (p=O.OOOl), and left ventricular systolic (p=0.0049) and end-diastolic (p=0.0021) pressure than survivors. They also exhibited larger left ventricular eod-diastolic (p=0.0046) and end-systolic (p=0.0027) volumes, lower ejection fraction (p=O.OOOl), and a greater proportion had severe mitral regurgitation (p=0.0095). Univariate analysis of histologic findings collected in a subgroup of patients referred since 1984 revealed a mild degree of myocellular hypertrophy to be associated with a poor prognosis (p=O.O217). Multivariate analysis selected only mean right atrial pressure (p=0.0022), ejection fraction (p=0.0089), and endsystolic volume (p =0.0265) as independent determinants of cardiac death. Our results suggest that cardiac catheteri- zation is mandatory for risk stratification of patients with idiopathic dilated cardiomyopathy, since it allows the assessment of hemodynamic, angiographic, and histopathologic features helpful in identifying patients with a poor prognosis.

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The course of idiopathic dilated cardiomyopathy in New Zealand.

Abstract: There are few studies of the course of this disease.Most of these come from the United States orRequests for reprints to

Cited by 46 publications

References 34 publications

Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan Results From a Nationwide Study

Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan Results From a Nationwide Study

Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure

Determinants of end‐stage idiopathic dilated cardiomyopathy: A multivariate analysis of 104 patients

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