The course of acute pancreatitis in children and potential simple laboratory markers of severity – A single Centre retrospective study

Abstract

Acute pancreatitis (AP) is an acute inflammatory process of the pancreas, induced by activated pancreatic proenzymes due to multiple causes such as trauma, infection, biliary and pancreatic abnormalities, systemic disease, medication and genetic predisposition. During AP, other regional tissues or remote organ systems can be involved in various degrees .1 According to the International Study Group of

Acute pancreatitis in children: risk factors, management, and outcomes

“…Much effort has been made to determine risk stratification tools [41–43]; however, efforts have previously been limited by prior lack of consensus severity classifications or inability to validate across different populations [36]. Recent studies utilizing consensus severity classifications have seen an association between high CRP at 48 h [44 ▪ ], high CRP at 48 h and WBC on admission [45 ▪ ], and elevated BUN + low albumin [46] is associated with more severe disease. In addition, matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP1) biomarkers [47 ▪ ], as well as IL-6 and MCP-1 cytokines [48] have been shown to be increased in a small study of patients who develop severe acute pancreatitis.…”