The course and prognosis of ulcerative colitis: Part I Short-term prognosis

An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area.

“…colitis is consistent with this view (Edwards and Truelove, 1963) and a similar viewpoint is reasonable for regional enteritis. Prevalence rates were computed using an estimated population of 298,000.…”

“…To compute these rates cases have been referred to the diagnostic group occupied on their last attendance at hospital before prevalence day. (Sloan et al, 1950;Edwards and Truelove, 1963). This probably reflects the fact that most hospital series include a number of Table IV and it can be seen that there has apparently been an increase in the incidence of the disease over the last six years.…”

“…This hypothesis was tested by comparing the clinical severity of the disease at first diagnosis for the two five-year periods 1951-55 and 1956-60 using the three categories of mild, moderate, and severe as defined by Edwards and Truelove (1963). Taking only the definite ulcerative colitis cases of recent onset depicted in Fig.…”

The Early Course and Prognosis of Ulcerative Colitis [Abridged]

“…Concerning prognosis, it has been claimed by Edwards & Truelove (1963) that the influence of the first attack may extend throughout the course of the disease. This at first appears to be true in our patients, but this appearance is misleading and is due to bias introduced by including deaths in the initial attack itself.…”

“…Unfortunately, with the notable exception of those by Rice-Oxley & Truelove (1950) and Edwards & Truelove (1963), most of these previous studies have failed to distinguish between patients who presented in their first attack of the disease, and who were followed up through its course, and those who were in a relapse of chronic established disease; in the latter the early course of their illness is uncertain.…”