The costochondral junction during later stages of intrauterine life, and abnormal growth patterns found in association with perinatal death.

Emery, John L.; Kalpaktsoglou, Pitsa K.

doi:10.1136/adc.42.221.1

Cited by 47 publications

(30 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ribs are the place where changes in bone growth are first identified and have similar morphological changes to those found in longer bones. 10,19 OCJ length in the 5 th and 6 th rib at birth is 120mm; considering total gestation time, the OCJ growth pattern is approximately 220µm per day. 10 Sets of cartilaginous cells are constantly deposited in the fetus's extracellular matrix throughout intrauterine development.…”

Section: Discussionmentioning

confidence: 99%

“…10,19 OCJ length in the 5 th and 6 th rib at birth is 120mm; considering total gestation time, the OCJ growth pattern is approximately 220µm per day. 10 Sets of cartilaginous cells are constantly deposited in the fetus's extracellular matrix throughout intrauterine development. 10 Several factors influence skeletal growth, maturation, and bone mass acquisition in newborns and infants, with a close and complex relationship between them.…”

Section: Discussionmentioning

confidence: 99%

“…10 Sets of cartilaginous cells are constantly deposited in the fetus's extracellular matrix throughout intrauterine development. 10 Several factors influence skeletal growth, maturation, and bone mass acquisition in newborns and infants, with a close and complex relationship between them. These factors are: genetic, nutritional, sexual, hormonal, local growth factors, and physical activity.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Historical Aspects of Osteochondral Junction Studies in Perinatal Autopsies

Salge¹

2017

ACP

View full text Add to dashboard Cite

Microscopic examination of the fetal ribs' osteochondral junction (OCJ) during perinatal autopsies is a reliable method to determine intrauterine fetal growth abnormalities. The ribs are ideal bones for studying fetal growth and development as they have the highest growth from a linear point of view during intrauterine life and are easy to access during autopsy examination. Understanding the normal histology of rib bones at different gestational ages is fundamental to recognize the postmortem pathological alterations. Moreover, examination of the OCJ can help to estimate the timing of the intrauterine insult that ultimately leads to the perinatal death.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Historical Aspects of Osteochondral Junction Studies in Perinatal Autopsies

Salge¹

2017

ACP

View full text Add to dashboard Cite

show abstract

“…In addition, as the fifth rib is considered to be the most rapidly growing bone during late pregnancy and infancy, microscopic examination of its costochondral junction is useful. 18 Here, alterations in growth are readily detected but the duration of preceding illness is influenced by the duration of gestation or postnatal age and any underlying subclinical rickets or scurvy. The sequence of changes and the interpretation of their duration, shown in Table 4, are adapted from the formulation of Emery, Sinclair-Smith and coworkers from 1964 to 1976 [17][18][19] .…”

Section: Stress Reactionsmentioning

confidence: 99%

“…18 Here, alterations in growth are readily detected but the duration of preceding illness is influenced by the duration of gestation or postnatal age and any underlying subclinical rickets or scurvy. The sequence of changes and the interpretation of their duration, shown in Table 4, are adapted from the formulation of Emery, Sinclair-Smith and coworkers from 1964 to 1976 [17][18][19] . Figure 3, A, illustrates normal rib-end growth with straight single file columns of activated chondrocytes in direct contact with capillaries.…”

Section: Stress Reactionsmentioning

confidence: 99%

The Pediatric Autopsy in Africa

Kaschula

2013

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.-Within the continent of Africa few countries have been able to practice pathology at the levels present in Europe and the Americas, and pediatric pathology does not exist as a stand-alone specialty. The author was invited by a colleague from Harvard Medical School, Boston, Massachusetts, to join a group of North American pathologists in presenting a course on the Contribution of Anatomic Pathology for advancing the health of women and children in Africa. The course was held in Ethiopia in June 2011, to review the current state of pediatric pathology in Africa and to provide resources/teaching for improving pediatric pathology services in low-resource settings.Objective.-To provide a succinct description of applicable autopsy techniques and the interpretation of gross, microscopic, and ancillary findings with respect to Africa's need to enhance the health of women and children. The author makes suggestions for obviating possible problems in anticipation of increased demands by national authorities and of public expectations of pathologists who usually have had only general training.Data Sources.-This article is based upon the author's personal experience of practicing pathology in Africa for the past 51 years, which has included visiting pathology laboratories in 9 African countries and interacting with colleagues in 18 additional African countries. The contents of this article are derived from personal observations, recent publications, and information gleaned from Internet sources.Conclusions.-Even without specific training in pediatric pathology, it is possible for pediatric autopsies to be undertaken in Africa and other resource-poor settings, in a manner that facilitates sound decision making for improving the health of women and children.(Arch Pathol Lab Med. 2013;137:756-766; doi: 10.5858/ arpa.2011-0589-RA) T here are several published textbooks [1][2][3][4][5][6] that describe how pediatric autopsies should be undertaken and adapted for particular circumstances. This article attempts to describe methods that are appropriate for general pathologists who practice in Africa and have not received specific training in pediatric autopsy techniques. These suggestions are adaptable to any resource-poor setting and are useful for application by any pathologist with any level of training. Africa has the highest maternal, perinatal, and infant mortality rates in the world, and unfortunately, these have not changed significantly in the past 2 decades. Much effort and resource expenditures have gone into addressing underlying socioeconomic, educational, cultural, and environmental factors without having given adequate attention to the skills and facilities needed to make accurate diagnoses upon which appropriate interventions should be made. It therefore is essential that pediatric autopsies be undertaken by appropriately skilled pathologists having access to affordable resources and who can be confident that health care decision makers will use their diagnoses. In Africa the role of pathologists in the over...

show abstract