The cost-effectiveness and cost-utility analysis of the use of enoxaparin compared with heparin for venous thromboembolism prophylaxis in medical inpatients in Iran

Amirsadri, Mohammadreza; Mousavi, Sarah; Karimipour, Ali

doi:10.1007/s40199-019-00292-1

Cited by 10 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More research is required to investigate the financial impact of thromboprophylaxis on patients in the cancer setting (such as co-pays, insurance coverage/denial, and preferred drugs covered), but results will clearly vary across countries and health care systems. Recent publications reporting cost-effectiveness of prophylaxis suggest that it will be cost saving across different health care systems, but only among higher-risk patient populations and with the use of lower-cost agents [ [14] , [15] , [16] , [17] ].…”

Section: What’s Behind the Implementation Gap?mentioning

confidence: 99%

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

Ades

Holmes

2023

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

Section: What’s Behind the Implementation Gap?mentioning

confidence: 99%

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

Ades

Holmes

2023

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

“…Enoxaparin for inpatients treatment of venous thromboembolism prophylaxis with moderate to high risk is not a cost-effective option in comparison to heparin from perspective of payer in Iran [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

QALY league table of Iran: a practical method for better resource allocation

Hashempour

Raei

Lari

et al. 2021

Cost Eff Resour Alloc

View full text Add to dashboard Cite

Background The limited health care resources cannot meet all the demands of the society. Thus, decision makers have to choose feasible interventions and reject the others. We aimed to collect and summarize the results of all cost utility analysis studies that were conducted in Iran and develop a Quality Adjusted Life Year (QALY) league table. Methods A systematic mapping review was conducted to identify all cost utility analysis studies done in Iran and then map them in a table. PubMed, Embase, Cochrane library, Web of Science, as well as Iranian databases like Iran Medex, SID, Magiran, and Barakat Knowledge Network System were all searched for articles published from the inception of the databases to January 2020. Additionally, Cost per QALY or Incremental Cost Utility Ratio (ICUR) were collected from all studies. The Joanna Briggs checklist was used to assess quality appraisal. Results In total, 51 cost-utility studies were included in the final analysis, out of which 14 studies were on cancer, six studies on coronary heart diseases. Two studies, each on hemophilia, multiple sclerosis and rheumatoid arthritis. The rest were on various other diseases. Markov model was the commonest one which has been applied to in 45% of the reviewed studies. Discount rates ranged from zero to 7.2%. The cost per QALY ranged from $ 0.144 in radiography costs for patients with some orthopedic problems to $ 4,551,521 for immune tolerance induction (ITI) therapy in hemophilia patients. High heterogeneity was revealed; therefore, it would be biased to rank interventions based on reported cost per QALY or ICUR. Conclusions However, it is instructive and informative to collect all economic evaluation studies and summarize them in a table. The information on the table would in turn be used to redirect resources for efficient allocation. in general, it was revealed that preventive programs are cost effective interventions from different perspectives in Iran.

show abstract

“…Furthermore, cost-effectiveness analysis is an economic evaluation method, which integrates safety, effectiveness and economical elements together. The proposed method focuses usually on pharmacologic prophylaxis of VTE, such as rivaroxaban versus warfarin in the treatment of morbidly obese patients with VTE 34 , enoxaparin versus heparin for medical inpatients in Iran on VTE prophylaxis 35 , and rivaroxaban versus apixaban for the initial and extended treatment of VTE and its recurrence in the UK 36 . However, at present, there is few research concerning the education on prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Knowledge Translation on Suspected Venous Thromboembolism in Hospitalized Patients

Peng

Zhang

Zeng

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Venous thromboembolism (VTE) is a preventable disease, but the implementing effect of preventive measures is not optimistic, and few patients receive optimal prophylaxis, which result in significant mortality, long-term complications and financial burden. The purpose of the article was to explore the effect of knowledge translation on suspected venous thromboembolism in hospitalized patients on admission.Methods The data of suspected VTE patients on admission was retrospectively collected from the Second Xiangya Hospital from October 2016 to September 2020. The Mann-Whitney test and Fisher’s exact test (or χ 2 test) were used to analyze the continuous and categorical variables. A decision tree model was developed to assess the cost-effectiveness of post-prophylaxis education compared with pre-prophylaxis education. The ranges of each parameter were set to perform sensitivity analysis.Results The awareness of preventable VTE has raised which expressed in the increasing use of Caprini score, incidence of VTE, and department distribution of suspected VTE patients on admission. The incremental cost effectiveness ratio was a negative value which was significantly smaller than willing to pay (WTP). When the WTP value was ¥212676, the probability of patients' acceptance was 84.3% in the post-prophylaxis group and 15.7% in the pre-prophylaxis group. No matter how WTP changed, the cost-effectiveness acceptability of post-prophylaxis education in preventing VTE after hospitalization was better than pre-prophylaxis education did. Conclusion Knowledge translation on VTE could have cost effectiveness on suspected VTE in hospitalized patients on admission.

show abstract

The cost-effectiveness and cost-utility analysis of the use of enoxaparin compared with heparin for venous thromboembolism prophylaxis in medical inpatients in Iran

Cited by 10 publications

References 19 publications

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

QALY league table of Iran: a practical method for better resource allocation

Effect of Knowledge Translation on Suspected Venous Thromboembolism in Hospitalized Patients

Contact Info

Product

Resources

About