During the three centuries from Homer to Hippocrates, views of human ageing and longevity evolved in a socio-cultural sense, with relationships to Greek medicine and science. I, as a biomedical scientist, examine ancient literature for roots of the idea that life-course outcomes can be influenced by tangible ‘natural’ factors, whether these are environmental or the result of lifestyle. The concept that an individual has any choice in health and ageing departs radically from ancient, persistent beliefs in the primacy of the supernatural, that the gods could predestine one's life span by birth or could alter it at any time.