The cosmetic treatment of wrinkles

Rona, Claudia; Vailati, F.; Berardesca, Enzo

doi:10.1111/j.1473-2130.2004.00054.x

Cited by 72 publications

(53 citation statements)

References 58 publications

(51 reference statements)

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“…Indeed, in cosmetology UA is often used for photoaging protection (2). It prevents and improves the appearance of wrinkles and age spots by restoring skin collagen structure and elasticity, stimulates collagen production in cultured fibroblasts and increases the production of ceramides in human epidermal keratinocytes and skin (3).…”

Section: Introductionmentioning

confidence: 99%

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells

Duval¹,

Harmand²,

Jayat-Vignoles³

et al. 2008

Oncol Rep

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Abstract. Ursolic acid (UA) is a pentacyclic triterpenoid compound which exists widely in nature and is known to have a pleitropic biological activity profile. For the last few decades, extensive work has been carried out to establish its biological activities and pharmacological actions. It is described as a promising chemopreventive agent with an antiproliferative effect on cancer cells that stems from its ability to induce apoptosis. We investigated and compared the role played by mitochondria during the apoptotic process induced by UA in human HaCaT-derived keratinotic cells and M4Beu human melanoma cells. In both cell lines, UA induced significant caspase-3 activation, the downstream central effector of apoptosis. Subsequent JC-1/TOTO-3 double staining clearly demonstrated that UA induces strong mitochondrial-transmembrane potential collapse in M4Beu cells, while mitochondria from HaCaT-treated cells remain largely unstimulated. This was confirmed by Western blot analysis, which revealed a Bax/Bcl-2-balance change in favor of Bax, the proapoptotic member, in UA-treated M4Beu cells. It can be concluded that UA induces apoptosis in M4Beu through the mitochondrial pathway, while other mechanisms are activated in the case of HaCaT cells. IntroductionAmong natural compounds, ursolic acid (UA), the most frequently studied natural triterpenic acid (1), seems to be a promising chemical entity for the protection of human skin. Indeed, in cosmetology UA is often used for photoaging protection (2). It prevents and improves the appearance of wrinkles and age spots by restoring skin collagen structure and elasticity, stimulates collagen production in cultured fibroblasts and increases the production of ceramides in human epidermal keratinocytes and skin (3). UA may also be an effective inhibitor of the UVA-modulated signal transduction pathway in human HaCaT cells, in which it significantly suppresses UVA-induced reactive oxygen species production and lipid peroxidation (4). Moreover, it possesses anti-tumor properties including the inhibition of skin tumorigenesis (5) and tumor promotion (6). UA also induces apoptosis in several cancer cell lines (7-13).Previously, we studied the effect of UA on human HaCaTderived keratinotic cells and M4Beu human melanoma cells with the intention of confirming its role as a promising candidate for skin cancer prevention. In those studies, we demonstrated for the first time that UA has a significant antiproliferative effect associated with the induction of the apoptotic process (14,15). In the literature, it is well established that the activation of the apoptotic transduction pathway is dependent on cell type and subcellular targets. The two main apoptotic pathways are the extrinsic and intrinsic pathways (16). The extrinsic pathway is characterized by death ligand attachment on extracellular receptors (e.g. TNF/TNF-R) with a subsequent caspase-8 activation, which in turn cleaves and activates caspase-3 (17). The intrinsic pathway is triggered by different mitochondrial stresses and i...

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Section: Introductionmentioning

confidence: 99%

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells

Duval¹,

Harmand²,

Jayat-Vignoles³

et al. 2008

Oncol Rep

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“…Dietary supplementation with vitamin E proved less effective in preventing cutaneous lipid peroxidation than topical treatment, likely because higher concentrations of this vitamin were achieved in the skin tissues after its topical administration [7]. In skin care products, vitamin E is used as moisturizing and particularly as anti-ageing, due to its ability to reduce fine lines, wrinkles and sagging induced by photo-ageing [8][9][10]. However, due to its sensitivity to atmospheric oxygen, vitamin E is poorly stable in topical formulations.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lipids and Emulsifiers on the Physicochemical and Sensory Properties of Cosmetic Emulsions Containing Vitamin E

et al. 2015

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Sensory properties are fundamental in determining the success of a cosmetic product. In this work, we assessed the influence of different oils and emulsifiers on the physicochemical and sensory properties of anti-ageing cosmetic O/W emulsions containing vitamin E acetate as active ingredient. No clear correlation between physicochemical properties and sensory characteristics was evidenced. Sensorial evaluation of these formulations pointed out that the emulsifier systems affected the perceived oiliness and absorbency during application of the product, thus influencing its acceptance. These results suggest the need for more detailed studies on the physicochemical factors involved in determining the consumers' acceptance.

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“…Retinol, polipeptidler ve bitkisel maddeler gibi hücre düzenleyiciler kollajen metabolizması üzerinde direkt etkilidirler ve kollajen ve elastik fiber oluşumunu uyarırlar. Retinol, hücre metabolizması üzerinde olumlu etkileri olan, antioksidan özellik gösteren ve epitelhücrelerinin doğru çalışması için gerekli olan hem kozmetik hem de ilaçta kullanılan bir bileşendir [44][45][46][47][48] .Retinolve türevleri yaşlanma karşıtı amaçla en fazla kullanılan maddelerdir. Güçlü bir antioksidandır.…”

Section: Kollajen Ve Elastin Ile Bu Yapıları Destekleyen Bileşenlerunclassified

Anti-Aging Cosmetics Approaches and Components in Products

Yapar¹,

Tanrıverdi²

2016

BSBD

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Cilt yaşlanması; iç veya dış faktörlerin veya bunların birlikteliğinin neden olduğu karmaşık biyolojik bir süreçtir. Gelişen üretim teknolojileri, farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ve yenilikçi bileşenlere dayalı yeni nesil kozmetik ürünler, temel kozmetik bakımdan ileri alternatifler sunmaktadır. İleri teknoloji kullanılarak üretilen kozmetik aktif bileşenleri, doğal kaynaklı hammaddelerin kozmetik bileşenleri olarak kullanımının artması ve farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ile geliştirilen kozmetik ürünler toplumların artan kozmetik beklentilerini karşılamayı hedeflemektedir. Bu derlemede, günümüzde bireylerin dış ve iç faktörler ile artan cilt yaşlanmasının, kozmetik ürün odaklı çözümleri özellikle bileşenler açısından irdelenmiş, yaşlanma karşıtı farklı yaklaşımlar özetlenmiş ve kullanılan taşıyıcı sistemler belirtilmiştir.

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The cosmetic treatment of wrinkles

Cited by 72 publications

References 58 publications

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells

Effects of Lipids and Emulsifiers on the Physicochemical and Sensory Properties of Cosmetic Emulsions Containing Vitamin E

Anti-Aging Cosmetics Approaches and Components in Products

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