The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder

Yang, Chang-Jiang; Tan, He-Ping; Yang, Fu-Yi; Wang, Heping; Liu, Chunling; He, Huang; Sang, Biao; Zhu, Xiaomei; Du, Yanqiu

doi:10.1016/j.rasd.2015.07.002

Cited by 26 publications

(29 citation statements)

References 60 publications

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“…Impairments in this pathway have been proposed as a sensitive and specific discriminating biomarker between patients with ASD and neurotypical controls, but their influence on the core diagnostic characteristics of ASD remains unclear. Some studies point out an association between melatonin and language skills, on the one hand, and serotonin and social skills, and stereotyped and repetitive behaviours, on the other. However, these findings have not been systematically replicated, probably owing to the fact that core symptoms can be translated into a wide variety of forms, each being linked to distinct neurobiological mechanisms …”

Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

“…core symptoms can be translated into a wide variety of forms, each being linked to distinct neurobiological mechanisms. 44 Consistent literature supports a role for a second neurotransmitter in the pathophysiology of ASD, namely the c-aminobutyric acid (GABA) system. In individuals with autism, lower brain GABA levels, reduced GABA A receptors in the superior frontal cortex, and deletions and duplications of the chromosome 15q (which contains genes coding for several subunits of the GABA A receptor) are evidence of impaired GABAergic function.…”

Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

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Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Deliens

Peigneux

2019

Develop Med Child Neuro

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Sleep disturbances are frequent and varied in autism spectrum disorder (ASD). Growing evidence suggests that sleep problems in children with ASD are driven by their clinical characteristics and psychiatric comorbidities. Therefore, the wide range of reported sleep disturbances reflects the marked heterogeneity of clinical pictures in ASD. Whether sleep disturbances and their various forms may, in turn, account for at least part of the phenotypical variability of ASD is a crucial question discussed in this review. We first outline studies both validating and challenging a bidirectional theoretical framework for sleep disorders in children with ASD. We then propose to extend this model by including cognition and sensory processing as key factors in the vicious circle linking sleep disorders and autistic symptoms. What this paper adds There is a bidirectional interplay between autism symptoms and sleep disturbances. Sleep influence on daytime cognitive and sensory skills should be further investigated.

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Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Deliens

Peigneux

2019

Develop Med Child Neuro

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“…Changes in redox signalling, epigenetic transcriptional factors, lipid and mitochondrial metabolism, ion channel/ gap junction/transporter regulation protein and posttranslational modification have also been reported (Frye et al, 2016;Rose et al, 2017). In addition, other biomarkers such as serotonin, p-cresol and cortisol have also been related to aetiology and behaviour in mental disorders such as Autism Spectrum Disorder (ASD) (Yang et al, 2015;Ferguson et al, 2016;Ooi et al, 2017;Kang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

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Summary In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with autism spectrum disorders (ASD) due to a dysbiosis in GM that can trigger onset, development or progression of ASD through the microbiota–gut–brain axis. The aim of this study is to carry out a systematic review of articles from the last 6 years that analyse GM in children with ASD compared to GM in control groups. Children with ASD showed a higher abundance of Roseburia and Candida genera, and lower abundance of Dialister, Bilophila, Veillonella, Streptococcus, Coprococcus and Prevotella genera. Those differences can be attributed to factors such as different nationalities, nature of control groups, place where the sample was taken, gastrointestinal (GI) problems or bacterial detection methods. It is still too early to define a specific GM profile of children with ASD, and future studies should focus on homogenizing the characteristics of samples and control groups. Furthermore, new multicentre studies should also focus on the impact of GM on GI physiology, neurophysiology and behaviour of children with ASD, and on performing psychometric analyses of the correlation between the severity of ASD behavioural symptoms and GM profiles.

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“…The secretion of this hormone increases in stress condition. This can lead to adrenal gland fatigue due to excessive secretion of cortisol [13]. Highest peak of cortisol release is 20-30 min after awakening.…”

Section: Cortisolmentioning

confidence: 99%

“…It might be due to acetylserotonin O-methyltransferase (ASMT) deficiency in melatonin pathway. However, this condition is also connected to cortisol level [13]. Melatonin deficiency might cause abnormal synaptogenesis.…”

Section: Melatoninmentioning

confidence: 99%

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

Lee¹

2019

Recent Advances in Biology and Medicine

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Autism spectrum disorder (ASD) is a single spectrum disorder. It is characterized by marked social deficit, stereotype behavior, flexibility, sensory sensitivity, and language impairment. However, ASD can also be accompanied by neuropathology and neuroendocrine dysfunction. Higher testosterone level intrauterine is assumed to increase ASD risk in early childhood. There is limited research about the correlation between ASD and neuroendocrine dysfunction.

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The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder

Cited by 26 publications

References 60 publications

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

An approach to gut microbiota profile in children with autism spectrum disorder

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

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