The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms

Abstract

Our findings suggest the importance of the CRF2 pathway in the control of adipocyte plasticity. Increased CRF2 activity in adipocytes induces browning of WAT, differentiation of BAT and is associated with a favorable metabolic phenotype in mice lacking CRF1. Circulating corticosterone represses CRF2 activity in adipocytes and may thus regulate adipocyte physiology through the modulation of the local CRF/urocortin system. Targeting CRF receptor signaling specifically in the adipose tissue may represent a novel approach to tackle obesity.

Hormonal factors in the control of the browning of white adipose tissue

“…An in vivo study also supported the corticotrophin-releasing factor/urocortin system in regulating browning through paracrine mechanisms in mice. Increased CRH-R2 activity in adipocytes induces browning of WAT, differentiation of BAT and is associated with a favorable metabolic phenotype in mice lacking CRH-R1 [85]. Furthermore, CRH also affects energy metabolism via its cross-talk with other hormones.…”

Einfluss von Urocortin auf die Skelettmuskulatur der osteoporotischen Ratte

“…Abb. (Seres et al 2004;Lu et al 2015). Über diese Mechanismen hat es erheblichen Einfluss auf die Energiebalance des Körpers.…”